Parallel Sites Implicate Functional Convergence of the Hearing Gene Prestin among Echolocating Mammals.

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	Parallel Sites Implicate Functional Convergence of the Hearing Gene Prestin among Echolocating Mammals.
	Liu Z 1; Qi FY 1,2; Zhou X 1; Ren HQ 1; Shi P[*]1
刊名	MOLECULAR BIOLOGY AND EVOLUTION
	2014
卷号	31 期号:9 页码:2415-2424
关键词	NLC bat convergent evolution dolphin echolocation
通讯作者	ship@mail.kiz.ac.cn
合作状况	其它
英文摘要	Echolocation is a sensory system whereby certain mammals navigate and forage using sound waves, usually in environments where visibility is limited. Curiously, echolocation has evolved independently in bats and whales, which occupy entirely different environments. Based on this phenotypic convergence, recent studies identified several echolocation-related genes with parallel sites at the protein sequence level among different echolocating mammals, and among these, prestin seems the most promising. Although previous studies analyzed the evolutionary mechanism of prestin, the functional roles of the parallel sites in the evolution of mammalian echolocation are not clear. By functional assays, we show that a key parameter of prestin function, 1/alpha, is increased in all echolocating mammals and that the N7T parallel substitution accounted for this functional convergence. Moreover, another parameter, V-1/2, was shifted toward the depolarization direction in a toothed whale, the bottlenose dolphin (Tursiops truncatus) and a constant-frequency (CF) bat, the Stoliczka's trident bat (Aselliscus stoliczkanus). The parallel site of I384T between toothed whales and CF bats was responsible for this functional convergence. Furthermore, the two parameters (1/alpha and V-1/2) were correlated with mammalian high-frequency hearing, suggesting that the convergent changes of the prestin function in echolocating mammals may play important roles in mammalian echolocation. To our knowledge, these findings present the functional patterns of echolocation-related genes in echolocating mammals for the first time and rigorously demonstrate adaptive parallel evolution at the protein sequence level, paving the way to insights into the molecular mechanism underlying mammalian echolocation.
收录类别	SCI
资助信息	This work was supported by a start-up fund of the “Hundreds-Talent Program” from the Chinese Academy of Sciences, Top Talents Program of Yunnan Province, and by grants from the National Natural ScienceFoundationofChinatoP.S.(31325013,31123005,and 31321002) and to Z.L. (31301013).
语种	英语
公开日期	2014-09-12
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/7999]
专题	昆明动物研究所_进化与功能基因组学昆明动物研究所_遗传资源与进化国家重点实验室
作者单位	1.State Key Laboratory of Genetic Resources and Evolution, Laboratory of Evolutionary and Functional Genomics, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China 2.University of the Chinese Academy of Sciences, Beijing, China
推荐引用方式 GB/T 7714	Liu Z,Qi FY,Zhou X,et al. Parallel Sites Implicate Functional Convergence of the Hearing Gene Prestin among Echolocating Mammals.[J]. MOLECULAR BIOLOGY AND EVOLUTION,2014,31(9):2415-2424.
APA	Liu Z,Qi FY,Zhou X,Ren HQ,&Shi P[*].(2014).Parallel Sites Implicate Functional Convergence of the Hearing Gene Prestin among Echolocating Mammals..MOLECULAR BIOLOGY AND EVOLUTION,31(9),2415-2424.
MLA	Liu Z,et al."Parallel Sites Implicate Functional Convergence of the Hearing Gene Prestin among Echolocating Mammals.".MOLECULAR BIOLOGY AND EVOLUTION 31.9(2014):2415-2424.