Iron Overload Coordinately Promotes Ferritin Expression and Fat Accumulation in Caenorhabditis elegans

	Iron Overload Coordinately Promotes Ferritin Expression and Fat Accumulation in Caenorhabditis elegans
	Wang HZ 1,2; Jiang X 1,2; Zhang YR 1; Zou XJ[]4; Liang B[]1; Wu JY 1,2; Zhang LQ 1,2; Huang JF 3
刊名	GENETICS
	2016
卷号	202 期号:1 页码:241-253
关键词	the serum and glucocorticoid inducible kinase SGK-1 Iron Lipid uptake Obesity C. elegans
通讯作者	xiaojuzou@163.com ; liangb@mail.kiz.ac.cn
合作状况	其它
英文摘要	The trace element iron is crucial for living organisms, since it plays essential roles in numerous cellular functions. Systemic iron overload and the elevated level of ferritin, a ubiquitous intracellular protein that stores and releases iron to maintain the iron homeostasis in cells, has long been epidemiologically associated with obesity and obesity-related diseases. However, the underlying mechanisms of this association remain unclear. Here, using Caenorhabditis elegans, we show that iron overload induces the expression of sgk-1, encoding the serum and glucocorticoid-inducible kinase, to promote the level of ferritin and fat accumulation. Mutation of cyp-23A1, encoding a homolog of human cytochrome P450 CYP7B1 that is related to neonatal hemochromatosis, further enhances the elevated expression of ftn-1, sgk-1, and fat accumulation. sgk-1 positively regulates the expression of acs-20 and vit-2, genes encoding homologs of the mammalian FATP1/4 fatty acid transport proteins and yolk lipoproteins, respectively, to facilitate lipid uptake and translocation for storage under iron overload. This study reveals a completely novel pathway in which sgk-1 plays a central role to synergistically regulate iron and lipid homeostasis, offering not only experimental evidence supporting a previously unverified link between iron and obesity, but also novel insights into the pathogenesis of iron and obesity-related human metabolic diseases.
收录类别	SCI
资助信息	This work was supported by the Strategic Priority Re- search Program of the Chinese Academy of Sciences (XDB13030600), the National Natural Science Foundation ofChina (31460268,31160216, 31171134, andU1202223),the Yunnan Natural Science Foundation (2013FA042 and 2011FZ179), the Yunnan Provincial Science and Technol- ogy Department (2014HB022), the Yunnan Overseas High- Level Talents Program (2015HA040 to B.L.), and the State Key Laboratory of Genetic Resources and Evolution (GREKF13-03).
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/9648]
专题	昆明动物研究所_结构生物信息学昆明动物研究所_动物模型与人类重大疾病机理重点实验室昆明动物研究所_遗传资源与进化国家重点实验室昆明动物研究所_脂类代谢与疾病
作者单位	1.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 2.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan 650204, China 3.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 4.Department of Life Science and Biotechnology, Key Laboratory of Special Biological Resource Development and Utilization of University in Yunnan Province, Kunming University, Kunming 650214, China
推荐引用方式 GB/T 7714	Wang HZ,Jiang X,Zhang YR,et al. Iron Overload Coordinately Promotes Ferritin Expression and Fat Accumulation in Caenorhabditis elegans[J]. GENETICS,2016,202(1):241-253.
APA	Wang HZ.,Jiang X.,Zhang YR.,Zou XJ[].,Liang B[].,...&Huang JF.(2016).Iron Overload Coordinately Promotes Ferritin Expression and Fat Accumulation in Caenorhabditis elegans.GENETICS,202(1),241-253.
MLA	Wang HZ,et al."Iron Overload Coordinately Promotes Ferritin Expression and Fat Accumulation in Caenorhabditis elegans".GENETICS 202.1(2016):241-253.