Single Base-Resolution Methylome of the Dizygotic Sheep

	Single Base-Resolution Methylome of the Dizygotic Sheep
	Wang YZ 1; Wu JH 2,3,4; Jiang Y 2,7; Wang W[]2; Dong Y[]1,2; Ma X 5; Liu B 2,3; Su R 2,6
刊名	PLOS ONE
	2015
卷号	10 期号:11 页码:e0142034
通讯作者	wwang@mail.kiz.ac.cn ; dongyang@dongyang-lab.org
合作状况	其它
英文摘要	Sheep is an important livestock in the world for meat, dairy and wool production. The third version of sheep reference genome has been recently assembled, but sheep DNA methylome has not been profiled yet. In this study, we report the comprehensive sheep methylome with 94.38% cytosine coverage at single base resolution by sequencing DNA samples from Longissimus dorsi of dizygotic Sunit sheep, which were bred in different habitats. We also compared methylomes between the twin sheep. DNA methylation status at genome-scale differentially methylated regions (DMRs), functional genomic regions and 248 DMR-containing genes were identified between the twin sheep. Gene ontology (GO) and KEGG annotations of these genes were performed to discover computationally predicted function. Lipid metabolism, sexual maturity and tumor-associated categories were observed to significantly enrich DMR-containing genes. These findings could be used to illustrate the relationship between phenotypic variations and gene methylation patterns.
收录类别	SCI
资助信息	This work was supported by the Chinese 863 program (2013AA102506), the National Natural Science Foundations of China (31201773 and 31560623), the open project of the State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences (GREKF13-02) to JW, and the China Postdoctoral Science Foundation (2014M562351) to JW.
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/9472]
专题	昆明动物研究所_基因起源组昆明动物研究所_遗传资源与进化国家重点实验室
作者单位	1.Kunming University of Science and Technology, Chenggong District, Kunming, China 2.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 3.Animal Husbandry Institute, Inner Mongolia Academy of Agricultural & Animal Husbandry Sciences, Hohhot, China 4.Inner Mongolia Prataculture Research Center, Chinese Academy of Science, Hohhot, China 5.Yunnan Agricultural University, Kunming, China 6.College of Animal Science, Inner Mongolia Agricultural University, Hohhot, China 7.College of Animal Science and Technology, Northwest A&F University, Yangling, China
推荐引用方式 GB/T 7714	Wang YZ,Wu JH,Jiang Y,et al. Single Base-Resolution Methylome of the Dizygotic Sheep[J]. PLOS ONE,2015,10(11):e0142034.
APA	Wang YZ.,Wu JH.,Jiang Y.,Wang W[].,Dong Y[].,...&Su R.(2015).Single Base-Resolution Methylome of the Dizygotic Sheep.PLOS ONE,10(11),e0142034.
MLA	Wang YZ,et al."Single Base-Resolution Methylome of the Dizygotic Sheep".PLOS ONE 10.11(2015):e0142034.