Rapid Functional Divergence of a Newly Evolved Polyubiquitin Gene in Drosophila and Its Role in the Trade-off between Male Fecundity and Lifespan

	Rapid Functional Divergence of a Newly Evolved Polyubiquitin Gene in Drosophila and Its Role in the Trade-off between Male Fecundity and Lifespan
	Zhan ZB 1,2; Ding Y 1,2; Zhao RP 1; Zhang Y 1; Yu HJ 1,3; Zhou Q 1; Yang S 1; Xiang H[]1; Wang W[]1
刊名	MOLECULAR BIOLOGY AND EVOLUTION
	2012
卷号	29 期号:5 页码:1407-1416
关键词	duplicated polyubiquitin gene CG11700 functional divergence reproductive cost
通讯作者	xiangh@mail.kiz.ac.cn ; wwang@mail.kiz.ac.cn
合作状况	其它
英文摘要	The cost of reproduction is a pivotal trade-off with various biological processes during the evolution of organisms. However, the genes and molecular mechanisms underlying the evolution of balancing reproductive capacity and its cost are still largely unknown. Here, we present a comprehensive study on the evolution, expression, and biological functions of a newly evolved pair of X-linked polyubiquitin tandemly duplicated genes, CG32744 and CG11700, of which the duplication event occurred in Drosophila melanogaster lineage after the split from D. simulans clade. We found that CG32744 retains conserved polyubiquitin-coding sequences across Drosophila species and is ubiquitously expressed, whereas CG11700 has accumulated numerous amino acid changes and shows a male-specific expression pattern. Null mutants of CG11700 have a higher male fecundity but shorter lifespan, whereas its overexpression decreases male fecundity. In contrast, the null mutants of the peptide-conserved CG32744 do not exhibit such phenotypes. These results suggest that CG11700 might have experienced neofunctionalization and evolved important functions in the trade-off between male fecundity and lifespan and that CG32744 likely has retained the ancestral function
收录类别	SCI
资助信息	This work was supported by an NSFC key grant (No. 30930056) to W.W., State Key Laboratory of Genetic Resources and Evo- lution Project (GREKF08-02), and a grant of The National Natural Science Foundation of China (NSFC) (30871342) to H.Y.
语种	英语
WOS记录号	WOS:000303603300010
公开日期	2012-05-31
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/6958]
专题	昆明动物研究所_基因起源组昆明动物研究所_遗传资源与进化国家重点实验室
作者单位	1.CAS-Max Planck Junior Research Group, State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China 2.Graduate University of the Chinese Academy Sciences, Beijing, China 3.Laboratory for Conservation and Utilization of Bio-resources and Human Genetics Center of Yunnan University, Kunming, China
推荐引用方式 GB/T 7714	Zhan ZB,Ding Y,Zhao RP,et al. Rapid Functional Divergence of a Newly Evolved Polyubiquitin Gene in Drosophila and Its Role in the Trade-off between Male Fecundity and Lifespan[J]. MOLECULAR BIOLOGY AND EVOLUTION,2012,29(5):1407-1416.
APA	Zhan ZB.,Ding Y.,Zhao RP.,Zhang Y.,Yu HJ.,...&Wang W[*].(2012).Rapid Functional Divergence of a Newly Evolved Polyubiquitin Gene in Drosophila and Its Role in the Trade-off between Male Fecundity and Lifespan.MOLECULAR BIOLOGY AND EVOLUTION,29(5),1407-1416.
MLA	Zhan ZB,et al."Rapid Functional Divergence of a Newly Evolved Polyubiquitin Gene in Drosophila and Its Role in the Trade-off between Male Fecundity and Lifespan".MOLECULAR BIOLOGY AND EVOLUTION 29.5(2012):1407-1416.