Familial longevity study reveals a significant association of mitochondrial DNA copy number between centenarians and their offspring

CORC > 昆明动物研究所 > 昆明动物研究所 > 遗传资源与进化国家重点实验室 > 分子人类学

	Familial longevity study reveals a significant association of mitochondrial DNA copy number between centenarians and their offspring
	He YH 1; Chen XQ 1; Liao XP 5; Liu YW 1,3; Pu SY 1; Yu Q 1,3; Sun HP 6; Jiang JJ 1,3; Yan DJ 2; Cai WW[*]2
刊名	Neurobiology of Aging
	2016
卷号	47 期号:X 页码:218.e11-218.e18.
关键词	Mitochondrial DNA Copy number Familial longevity Single-stranded DNA-binding protein 4
通讯作者	caiww591020@163.com ; kongqp@mail.kiz.ac.cn
合作状况	其它
英文摘要	Reduced mitochondrial function is an important cause of aging and age-related diseases. We previously revealed a relatively higher level of mitochondrial DNA (mtDNA) content in centenarians. However, it is still unknown whether such an mtDNA content pattern of centenarians could be passed on to their offspring and how it was regulated. To address these issues, we recruited 60 longevity families consisting of 206 family members (cohort 1) and explored their mtDNA copy number. The results showed that the first generation of the offspring (F1 offspring) had a higher level of mtDNA copy number than their spouses (p < 0.05) independent of a gender effect. In addition, we found a positive association of mtDNA copy number in centenarians with that in F1 offspring (r = 0.54, p = 0.0008) but not with that in F1 spouses. These results were replicated in another independent cohort consisting of 153 subjects (cohort 2). RNA sequencing analysis suggests that the single-stranded DNA-binding protein 4 was significantly associated with mtDNA copy number and was highly expressed in centenarians as well as F1 offspring versus the F1 spouses, thus likely regulates the mtDNA copy number in the long-lived family members. In conclusion, our results suggest that the pattern of high mtDNA copy number is likely inheritable, which may act as a favorable factor to familial longevity through assuring adequate energy supply.
收录类别	SCI
资助信息	This work was supported bygrants from National Basic Research Program of China (2013CB530802), the International Partnership Program of Chinese Academy of Sciences (152453KYSB20160006), National Natural Science Foundation of China (81671404, 81500670, 31460290), Yunnan Applied Basic Research Project (2013FB069), the open project from State Key Laboratory of Genetic Resources and Evolution (GREKF16-10), the Department of Science and Technology of Hainan Province (KJHZ2013-16), and the Youth Innovation Promotion Association of Chinese Academy of Sciences.
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/10456]
专题	昆明动物研究所_分子人类学昆明动物研究所_遗传资源与进化国家重点实验室
作者单位	1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming, China 2.Department of Biochemistry and Molecular Biology, Hainan Medical College, Haikou, China 3.Kunming College of Life Science, University of Chinese Academy of Sciences, Beijing, China 4.Department of Biology, Hainan Medical College, Haikou, China 5.Department of Neurology, The Affiliated Hospital of Hainan Medical College, Haikou, China 6.Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Soochow University, Suzhou, China
推荐引用方式 GB/T 7714	He YH,Chen XQ,Liao XP,et al. Familial longevity study reveals a significant association of mitochondrial DNA copy number between centenarians and their offspring[J]. Neurobiology of Aging,2016,47(X):218.e11-218.e18..
APA	He YH.,Chen XQ.,Liao XP.,Liu YW.,Pu SY.,...&Lin R.(2016).Familial longevity study reveals a significant association of mitochondrial DNA copy number between centenarians and their offspring.Neurobiology of Aging,47(X),218.e11-218.e18..
MLA	He YH,et al."Familial longevity study reveals a significant association of mitochondrial DNA copy number between centenarians and their offspring".Neurobiology of Aging 47.X(2016):218.e11-218.e18..