Structure and bioactivity of triterpenoids from the stems of Schisandra sphenanthera

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 分子免疫药理学

	Structure and bioactivity of triterpenoids from the stems of Schisandra sphenanthera
	Liang CQ 1,2,3; Luo RH 4; Yan JM 1; Li Y 1; Li XN 1; Shi YM 1,3; Shang SZ 1,3; Gao ZH 1,3; Yang LM 4; Zheng YT 4
刊名	ARCHIVES OF PHARMACAL RESEARCH
	2014
卷号	37 期号:2 页码:168-174
关键词	Triterpenoid Cytotoxicity Anti-HIV-1 Schisandra sphenanthera
通讯作者	xwl@mail.kib.ac.cn ; hdsun@mail.kib.ac.cn
合作状况	其它
英文摘要	Two new triterpenoids, schisphendilactone A and B (1 and 2), together with three known triterpenoids, were isolated from the stems of Schisandra sphenanthera. Their structures were elucidated by spectroscopic methods, and the absolute configuration of 1 was determined by single-crystal X-ray diffraction. Compound 2 showed moderate inhibitory activity against SW480 cancer cell line, and compound 5 exhibited promising anti-HIV-1 activity with EC50 value of 0.52 mu g ml(-1) and therapeutic index value of 117.12.
收录类别	SCI
资助信息	This project was supported financially by the projects from the Chinese Academy of Sciences (KSCX2-EW-Q-10), the NSFC (81102483, 81001462 and 30830115), the Major State Basic Research Development Program of China (2009CB522300 and 2009CB940900), the Key Scientific and Technological Program of China (2012ZX10001-006), the project of recruited top talent of sciences and technology of Yunnan Province (2009C1120), and the Natural Science Foundation of Yunnan Province (2012FB178).
语种	英语
WOS记录号	WOS:000330958500002
公开日期	2014-10-16
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/8059]
专题	昆明动物研究所_分子免疫药理学昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位	1.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, People’s Republic of China 2.Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, Yunnan 3.University of Chinese Academy of Sciences, Beijing 100039, People’s Republic of China 4.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, People’s Republic of China
推荐引用方式 GB/T 7714	Liang CQ,Luo RH,Yan JM,et al. Structure and bioactivity of triterpenoids from the stems of Schisandra sphenanthera[J]. ARCHIVES OF PHARMACAL RESEARCH,2014,37(2):168-174.
APA	Liang CQ.,Luo RH.,Yan JM.,Li Y.,Li XN.,...&Sun HD[*].(2014).Structure and bioactivity of triterpenoids from the stems of Schisandra sphenanthera.ARCHIVES OF PHARMACAL RESEARCH,37(2),168-174.
MLA	Liang CQ,et al."Structure and bioactivity of triterpenoids from the stems of Schisandra sphenanthera".ARCHIVES OF PHARMACAL RESEARCH 37.2(2014):168-174.