Aged Chinese rhesus macaques suffer severe phenotypic T- and B-cell aging accompanied with sex differences

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 分子免疫药理学

	Aged Chinese rhesus macaques suffer severe phenotypic T- and B-cell aging accompanied with sex differences
	Zheng HY 1,2; Zhang MX 2,3; Pang W 2; Zheng YT[*]1,2
刊名	EXPERIMENTAL GERONTOLOGY
	2014
卷号	55 期号:X 页码:113-119
关键词	Adaptive immunity Age Chinese rhesus macaques Immunosenescence Sex
通讯作者	zhengyt@mail.kiz.ac.cn
英文摘要	The elderly usually suffer from increased morbidity and mortality due to infectious diseases, and this process may be attributed to diminishing immune protection with age. This phenomenon is commonly referred to as immunosenescence. However, this theory is still not well defined. Non-human primates serve as a favorable model to facilitate the study in aging of the immune system. Here, we investigated the phenotypic features of T- and B-cell aging in peripheral blood from Chinese rhesus macaques, which included (1) a decrease of CD4/CD8 ratio; (2) a loss of naive T cells accompanied with elevated proliferation and expansion of effector memory subset; (3) a reduction in B cell numbers and a shift from naive B cells towards memory phenotype; and (4) increased levels of PD-1 expression in T cells and CD95 expression in B cells. Moreover, an accelerated decline in CD4(+) T cells and naive T cells was found in male macaques, giving them a more severe immune risk profile. These data indicated that Chinese rhesus macaques share a significant homology with humans in phenotypic aging of adaptive immunity, and may be an appropriate animal model for human aging research.
收录类别	SCI
资助信息	The work was supported by the National Basic Research Program of China (2012CBA01305), the Knowledge Innovation Program of CAS (KSCX2-EW-R-13), the National Natural Science Foundation of China (81172876; 81273251; U1202228), and the Key Scientific and Techno- logical Program of China (2013ZX10001-002; 2012ZX10001-007).
语种	英语
WOS记录号	WOS:000335929300015
公开日期	2014-06-04
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/7864]
专题	昆明动物研究所_分子免疫药理学昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位	1.School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230026, China 2.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China 3.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan 650204, China
推荐引用方式 GB/T 7714	Zheng HY,Zhang MX,Pang W,et al. Aged Chinese rhesus macaques suffer severe phenotypic T- and B-cell aging accompanied with sex differences[J]. EXPERIMENTAL GERONTOLOGY,2014,55(X):113-119.
APA	Zheng HY,Zhang MX,Pang W,&Zheng YT[*].(2014).Aged Chinese rhesus macaques suffer severe phenotypic T- and B-cell aging accompanied with sex differences.EXPERIMENTAL GERONTOLOGY,55(X),113-119.
MLA	Zheng HY,et al."Aged Chinese rhesus macaques suffer severe phenotypic T- and B-cell aging accompanied with sex differences".EXPERIMENTAL GERONTOLOGY 55.X(2014):113-119.