Lignans with Anti-HIV Activity from Schisandra propinqua var. sinensis

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 分子免疫药理学

	Lignans with Anti-HIV Activity from Schisandra propinqua var. sinensis
	Li XN 1,4; Pu JX 1; Du X 1; Yang LM 2; An HM 3; Lei C 1; He F 1; Luo X 1; Zheng YT 2; Lu Y 3
刊名	JOURNAL OF NATURAL PRODUCTS
	2009
卷号	72 期号:6 页码:1133-1141
ISSN号	0163-3864
通讯作者	hdsun@mail.kib.ac.cn ; xwl@mail.kib.ac.cn
合作状况	其它
英文摘要	Fourteen new lignans, tiegusanins A-N (1-14), together with 13 known compounds were isolated from the aerial parts of Schisandra propinqua var. sinensis. The structures and absolute configurations of 1-13 were established using a combination of spectroscopic techniques. Compound 14 was obtained as a racemate. When evaluated for inhibitory activity against HIV-1, tiegusanin G (7) showed anti-HIV-1 activity with an EC(50) value of 7.9 mu M and a therapeutic index (TI) of more than 25.
收录类别	SCI
资助信息	This work was supported financially by the NSFC (No. 30830115 and 20802082), the Major State Basic Research Development Program of China (No. 2009CB522303 and 2009CB940900), a project of the Chinese Academy of Sciences ("Xibuzhiguang" to W.L.X. and No. KS
原文出处	20097261133.pdf
语种	英语
公开日期	2010-08-24
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/4667]
专题	昆明动物研究所_分子免疫药理学昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位	1.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, People’s Republic of China 2.Key Laboratory of Animal Models and Human Disease Mechanisms and Laboratory of Molecular Immunopharmacology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, People’s Republic of China 3.Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Peking 100050, People’s Republic of China 4.Graduate School of the Chinese Academy of Sciences, Beijing 100039, People’s Republic of China
推荐引用方式 GB/T 7714	Li XN,Pu JX,Du X,et al. Lignans with Anti-HIV Activity from Schisandra propinqua var. sinensis[J]. JOURNAL OF NATURAL PRODUCTS,2009,72(6):1133-1141.
APA	Li XN.,Pu JX.,Du X.,Yang LM.,An HM.,...&Sun HD[*].(2009).Lignans with Anti-HIV Activity from Schisandra propinqua var. sinensis.JOURNAL OF NATURAL PRODUCTS,72(6),1133-1141.
MLA	Li XN,et al."Lignans with Anti-HIV Activity from Schisandra propinqua var. sinensis".JOURNAL OF NATURAL PRODUCTS 72.6(2009):1133-1141.