No association between Y chromosomal haplogroups and severe acne in the Han Chinese population

CORC > 昆明动物研究所 > 昆明动物研究所 > 遗传资源与进化国家重点实验室 > 分子进化基因组学

	No association between Y chromosomal haplogroups and severe acne in the Han Chinese population
	Guo MH 1; Wu WJ 1; Fan L 2; Peng MS 2,3; Yang JK 3,4; Zhang W 2,5; Hao F 6; Xie HF 7; He L[]1; Zhang YP[]2,3,4
刊名	JOURNAL OF HUMAN GENETICS
	2014
卷号	59 期号:8 页码:475-476
通讯作者	helikm2662@126.com ; zhangyp@mail.kiz.ac.cn
英文摘要	Severe acne presents sexual dimorphism in its incidence in Chinese population. It is more prevalent in males. To assess the possible Y chromosomal contribution to severe acne risk in Han Chinese males, we analyzed 2041 Y chromosomal SNPs (Y-SNPs) in 725 severe acne cases and 651 controls retrieved from our recent genome-wide association study data. After data filtering, we assigned 585 cases and 494 controls into 12 Y chromosomal haplogroups based on 307 high-confidence Y-SNPs. No statistically significant difference in the distribution of Y chromosomal haplogroup frequencies was observed between the case and control groups. Our results showed a lack of association between the incidence of severe acne and the different Y chromosomal haplogroup in the Han Chinese population.
收录类别	SCI
资助信息	This study was supported by grants from the National Natural Science Foundation of China (81060123, 81360234), the Yunnan Natural Science Foundation (2011FA028, 2011FB175, 2012FB004) and R&D Infrastructure and Facility Development Program of Yunnan Province (2011-307).
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/9253]
专题	昆明动物研究所_分子进化基因组学昆明动物研究所_动物模型与人类重大疾病机理重点实验室昆明动物研究所_遗传资源与进化国家重点实验室昆明动物研究所_重大疾病机理的遗传学
作者单位	1.Kunming Medical University, and Institute of Dermatology & Venereology of Yunnan Province, Kunming, China 2.KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming, China 3.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 4.Laboratory for Conservation and Utilization of Bio-Resources & Key Laboratory for Microbial Resources of the Ministry of Education, Yunnan University, Kunming, China 5.Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 6.Department of Dermatology, Southwest Hospital, Third Military Medical University, Chongqing, China 7.Department of Dermatology, Xiangya Hospital Central South University, Changsha, China 8.Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China 9.Department of Dermatology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China 10.Department of Dermatology, Second Affiliated Hospital of Fujian Medical University, Quanzhou, China
推荐引用方式 GB/T 7714	Guo MH,Wu WJ,Fan L,et al. No association between Y chromosomal haplogroups and severe acne in the Han Chinese population[J]. JOURNAL OF HUMAN GENETICS,2014,59(8):475-476.
APA	Guo MH.,Wu WJ.,Fan L.,Peng MS.,Yang JK.,...&Pang Q.(2014).No association between Y chromosomal haplogroups and severe acne in the Han Chinese population.JOURNAL OF HUMAN GENETICS,59(8),475-476.
MLA	Guo MH,et al."No association between Y chromosomal haplogroups and severe acne in the Han Chinese population".JOURNAL OF HUMAN GENETICS 59.8(2014):475-476.