Complex Evolutionary Patterns Revealed by Mitochondrial Genomes of the Domestic Horse

CORC > 昆明动物研究所 > 昆明动物研究所 > 遗传资源与进化国家重点实验室 > 分子进化基因组学

	Complex Evolutionary Patterns Revealed by Mitochondrial Genomes of the Domestic Horse
	Ning T 1,2,3; Li J 4,5; Lin K 6; Xiao H 7; Wylie S 8; Hua S 9; Li H[]6; Zhang YP[]1,3
刊名	CURRENT MOLECULAR MEDICINE
	2014
卷号	14 期号:10 页码:1286-1298
关键词	Horse mitochondria population history recombination selection
通讯作者	lihaipeng@picb.ac.cn ; zhangyp@mail.kiz.ac.cn
合作状况	其它
英文摘要	The domestic horse is the most widely used and important stock and recreational animal, valued for its strength and endurance. The energy required by the domestic horse is mainly supplied by mitochondria via oxidative phosphorylation. Thus, selection may have played an essential role in the evolution of the horse mitochondria. Besides, demographic events also affect the DNA polymorphic pattern on mitochondria. To understand the evolutionary patterns of the mitochondria of the domestic horse, we used a deep sequencing approach to obtain the complete sequences of 15 mitochondrial genomes, and four mitochondrial gene sequences, ND6, ATP8, ATP6 and CYTB, collected from 509, 363, 363 and 409 domestic horses, respectively. Evidence of strong substitution rate heterogeneity was found at nonsynonymous sites across the genomes. Signatures of recent positive selection on mtDNA of domestic horse were detected. Specifically, five amino acids in the four mitochondrial genes were identified as the targets of positive selection. Coalescent-based simulations imply that recent population expansion is the most probable explanation for the matrilineal population history for domestic horse. Our findings reveal a complex pattern of non-neutral evolution of the mitochondrial genome in the domestic horses.
收录类别	SCI
资助信息	This work was funded by grants provided by the National Program on Key Basic Research Project China (2007CB815700), the Science Foundation of the Chinese Academy of Sciences, the NSFC and Yunnan Province Union Fund (U0836602), the National Natural Science Foundation of China (30760038，31172073 and 31301014), the Applied Basic Research Programs of Yunnan Province (2011FZ001), the Scientific Research Foundation of Education Bureau of Yunnan Province (2010Y502 and 2011Y104) and by the Scientific Research Foundation of Kunming University (YJL11003).
语种	英语
WOS记录号	WOS:000346161900007
公开日期	2015-01-12
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/8217]
专题	昆明动物研究所_分子进化基因组学昆明动物研究所_遗传资源与进化国家重点实验室
作者单位	1.Laboratory for Conservation and Utilization of Bio-resource and Key Laboratory for Microbial Resources of the Ministry of Education, Yunnan University, Yunnan, China 2.Laboratory for Animal Genetic Diversity and Evolution of Higher Education in Yunnan Province, Yunnan University, Yunnan, China 3.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Yunnan, China 4.Agriculture College, Kunming University, Yunnan, China 5.Engineering Research Center for Urban Modern Agriculture of Higher Education in Yunnan Province, Kunming University, Yunnan, China 6.CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China 7.School of Life Sciences, Yunnan University, Yunnan, China 8.Western Australian State Agricultural Biotechnology Centre, Murdoch University, Perth, Australia 9.Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Yunnan, China
推荐引用方式 GB/T 7714	Ning T,Li J,Lin K,et al. Complex Evolutionary Patterns Revealed by Mitochondrial Genomes of the Domestic Horse[J]. CURRENT MOLECULAR MEDICINE,2014,14(10):1286-1298.
APA	Ning T.,Li J.,Lin K.,Xiao H.,Wylie S.,...&Zhang YP[*].(2014).Complex Evolutionary Patterns Revealed by Mitochondrial Genomes of the Domestic Horse.CURRENT MOLECULAR MEDICINE,14(10),1286-1298.
MLA	Ning T,et al."Complex Evolutionary Patterns Revealed by Mitochondrial Genomes of the Domestic Horse".CURRENT MOLECULAR MEDICINE 14.10(2014):1286-1298.