Evolutionary and Functional Novelty of Pancreatic Ribonuclease: a Study of Musteloidea (order Carnivora)

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	Evolutionary and Functional Novelty of Pancreatic Ribonuclease: a Study of Musteloidea (order Carnivora)
	Liu J 1; Wang XP 1; Cho S 2; Lim BK 3; Irwin DM 4; Ryder OA 5; Zhang YP[]6; Yu L[]1,7
刊名	SCIENTIFIC REPORTS
	2014
卷号	4 期号:X 页码:e5070
通讯作者	zhangyp@mail.kiz.ac.cn ; yuli-1220@163.com
英文摘要	Pancreatic ribonuclease (RNASE1) is a digestive enzyme that has been one of the key models in studies of evolutionary innovation and functional diversification. It has been believed that the RNASE1 gene duplications are correlated with the plant-feeding adaptation of foregut-fermenting herbivores. Here, we characterized RNASE1 genes from Caniformia, which has a simple digestive system and lacks microbial digestion typical of herbivores, in an unprecedented scope based on both gene sequence and tissue expression analyses. Remarkably, the results yielded new hypotheses regarding the evolution and the function of Caniformia RNASE1 genes. Four independent gene duplication events in the families of superfamily Musteloidea, including Procyonidae, Ailuridae, Mephitidae and Mustelidae, were recovered, rejecting previous Mustelidae-specific duplication hypothesis, but supporting Musteloidea duplication hypothesis. Moreover, our analyses revealed pronounced differences among the RNASE1 gene copies regarding their selection pressures, pI values and tissue expression patterns, suggesting the differences in their physiological functions. Notably, the expression analyses detected the transcription of a RNASE1 pseudogene in several tissues, raising the possibility that pseudogenes are also a potential source during the RNase functional diversification. In sum, the present work demonstrated a far more complex and intriguing evolutionary pattern and functional diversity of mammalian ribonuclease than previously thought.
收录类别	SCI
资助信息	This work was supported by Grants from the State Key Basic Research and Development Plan (No. 2007CB411600), National Natural Science Foundation of China.
语种	英语
WOS记录号	WOS:000336364900001
公开日期	2014-10-15
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/8046]
专题	昆明动物研究所_分子进化基因组学昆明动物研究所_遗传资源与进化国家重点实验室
作者单位	1.Laboratory for Conservation and Utilization of Bio-resource & Key Laboratory for Microbial Resources of the Ministry of Education, YunnanUniversity,Kunming650091,PRChina 2.epartmentofBiology,CreightonUniversity,Omaha,Nebraska,UnitedStatesof America 3.Department of Natural History, Royal Ontario Museum, 100 Queen’s Park, Toronto, Ontario M5S 2C6, Canada (BKL) 4.Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada 5.San Diego Zoo Institute for ConservationResearch, 15600 SanPasqualValley Road,Escondido,CA92027 USA 6.State KeyLaboratoryof GeneticResources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 7.Key Laboratory for Animal Genetic Diversity and Evolution of High Education in Yunnan Province, Yunnan University, Kunming, Yunnan 650091, China
推荐引用方式 GB/T 7714	Liu J,Wang XP,Cho S,et al. Evolutionary and Functional Novelty of Pancreatic Ribonuclease: a Study of Musteloidea (order Carnivora)[J]. SCIENTIFIC REPORTS,2014,4(X):e5070.
APA	Liu J.,Wang XP.,Cho S.,Lim BK.,Irwin DM.,...&Yu L[*].(2014).Evolutionary and Functional Novelty of Pancreatic Ribonuclease: a Study of Musteloidea (order Carnivora).SCIENTIFIC REPORTS,4(X),e5070.
MLA	Liu J,et al."Evolutionary and Functional Novelty of Pancreatic Ribonuclease: a Study of Musteloidea (order Carnivora)".SCIENTIFIC REPORTS 4.X(2014):e5070.