Signature of Balancing Selection at the MC1R Gene in Kunming Dog Populations

CORC > 昆明动物研究所 > 昆明动物研究所 > 遗传资源与进化国家重点实验室 > 分子进化基因组学

	Signature of Balancing Selection at the MC1R Gene in Kunming Dog Populations
	Wang GD 1; Cheng LG 3; Fan RX 2; Irwin DM 1,4,5; Tang SS 3; Peng JG 3; Zhang YP[*]1,2
刊名	PLOS ONE
	2013
卷号	8 期号:2 页码:e55469
通讯作者	zhangyp1@263.net.cn
合作状况	其它
英文摘要	Coat color in dog breeds is an excellent character for revealing the power of artificial selection, as it is extremely diverse and likely the result of recent domestication. Coat color is generated by melanocytes, which synthesize pheomelanin (a red or yellow pigment) or eumelanin (a black or brown pigment) through the pigment type-switching pathway, and is regulated by three genes in dogs: MC1R (melanocortin receptor 1), CBD103 (beta-defensin 103), and ASIP (agouti-signaling protein precursor). The genotypes of these three gene loci in dog breeds are associated with coat color pattern. Here, we resequenced these three gene loci in two Kunming dog populations and analyzed these sequences using population genetic approaches to identify evolutionary patterns that have occurred at these loci during the recent domestication and breeding of the Kunming dog. The analysis showed that MC1R undergoes balancing selection in both Kunming dog populations, and that the Fst value for MC1R indicates significant genetic differentiation across the two populations. In contrast, similar results were not observed for CBD103 or ASIP. These results suggest that high heterozygosity and allelic differences at the MC1R locus may explain both the mixed color coat, of yellow and black, and the difference in coat colors in both Kunming dog populations.
收录类别	SCI
资助信息	This work was supported by grants from the National Basic Research Program of China (973 Program, 2013CB835200), National Natural Science Foundation of China (91231108), Chinese Academy of Sciences, and Bureau of Science and Technology of Yunnan Province.
语种	英语
WOS记录号	WOS:000315965100022
公开日期	2013-09-16
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/7634]
专题	昆明动物研究所_分子进化基因组学昆明动物研究所_遗传资源与进化国家重点实验室
作者单位	1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 2.Laboratory for Conservation and Utilization of Bio-resources, Yunnan University, Kunming, China 3.Kunming Police Dog Base, Ministry of Public Security, Kunming, China 4.Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada 5.Banting and Best Diabetes Centre, University of Toronto, Ontario, Canada
推荐引用方式 GB/T 7714	Wang GD,Cheng LG,Fan RX,et al. Signature of Balancing Selection at the MC1R Gene in Kunming Dog Populations[J]. PLOS ONE,2013,8(2):e55469.
APA	Wang GD.,Cheng LG.,Fan RX.,Irwin DM.,Tang SS.,...&Zhang YP[*].(2013).Signature of Balancing Selection at the MC1R Gene in Kunming Dog Populations.PLOS ONE,8(2),e55469.
MLA	Wang GD,et al."Signature of Balancing Selection at the MC1R Gene in Kunming Dog Populations".PLOS ONE 8.2(2013):e55469.