The chemokine CXCL13 in lung cancers associated with environmental polycyclic aromatic hydrocarbons pollution

	The chemokine CXCL13 in lung cancers associated with environmental polycyclic aromatic hydrocarbons pollution
	Wang GZ 1; Cheng X 1; Chen HB 4; Li GF 3; Huang ZL 2; Zhou YC 3; Feng L 5; Wei MM 1; Zhou B 1; Qu LW 1
刊名	eLife
	2015
卷号	4 期号:X 页码:e09419
关键词	human human biology medicine
通讯作者	gbzhou@ioz.ac.cn
合作状况	其它
英文摘要	More than 90% of lung cancers are caused by cigarette smoke and air pollution, with polycyclic aromatic hydrocarbons (PAHs) as key carcinogens. In Xuanwei City of Yunnan Province, the lung cancer incidence is among the highest in China, attributed to smoky coal combustion-generated PAH pollution. Here, we screened for abnormal inflammatory factors in non-small cell lung cancers (NSCLCs) from Xuanwei and control regions (CR) where smoky coal was not used, and found that a chemokine CXCL13 was overexpressed in 63/70 (90%) of Xuanwei NSCLCs and 44/71 (62%) of smoker and 27/60 (45%) of non-smoker CR patients. CXCL13 overexpression was associated with the region Xuanwei and cigarette smoke. The key carcinogen benzo(a)pyrene (BaP) induced CXCL13 production in lung epithelial cells and in mice prior to development of detectable lung cancer. Deficiency in Cxcl13 or its receptor, Cxcr5, significantly attenuated BaP-induced lung cancer in mice, demonstrating CXCL13's critical role in PAH-induced lung carcinogenesis.
收录类别	SCI
资助信息	This work was supported by the National Natural Science Funds for Distinguished Young Scholar (81425025), the National Key Program for Basic Research (2012CB910800), the National Nat- ural Science Foundation of China (81171925 and 81201537), and grants from the State Key Labora- tory of Medical Genomics.
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/9482]
专题	昆明动物研究所_分子病理学
作者单位	1.State Key Laboratory of Membrane Biology, Institute of Zoology, University of Chinese Academy of Sciences, Beijing, China 2.Department of Thoracic Surgery, Cancer Center, Sun Yat-Sen University, Guangzhou, China 3.Department of Thoracic Surgery, Yunnan Tumor Hospital, Kunming Medical University, Kunming, China 4.Department of Pathology, The First People's Hospital of Qujing, Qujing, China 5.Department of Pathology, The People's Liberation Army General Hospital, Beijing, China. 6.Laboratory of Molecular and Experimental Pathology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China
推荐引用方式 GB/T 7714	Wang GZ,Cheng X,Chen HB,et al. The chemokine CXCL13 in lung cancers associated with environmental polycyclic aromatic hydrocarbons pollution[J]. eLife,2015,4(X):e09419.
APA	Wang GZ.,Cheng X.,Chen HB.,Li GF.,Huang ZL.,...&Huang YC.(2015).The chemokine CXCL13 in lung cancers associated with environmental polycyclic aromatic hydrocarbons pollution.eLife,4(X),e09419.
MLA	Wang GZ,et al."The chemokine CXCL13 in lung cancers associated with environmental polycyclic aromatic hydrocarbons pollution".eLife 4.X(2015):e09419.