Dynamic expression of the LAP family of genes during early development of Xenopus tropicalis
Yang QT1,2; Lv XY1; Kong QH2; Li CC2; Zhou Q[*]1; Mao BY[*]2
刊名SCIENCE CHINA-LIFE SCIENCES
2011
卷号54期号:10页码:897-903
关键词Xenopus tropicalis LAP gene family Densin Erbin Scrib Lano expression pattern
通讯作者pkdzhou@126.com ; mao@mail.kiz.ac.cn
合作状况其它
英文摘要The leucine-rich repeats and PDZ (LAP) family of genes are crucial for the maintenance of cell polarity as well as for epithelial homeostasis and tumor suppression in both vertebrates and invertebrates. Four members of this gene family are known: densin, erbin, scribble and lano. Here, we identified the four members of the LAP gene family in Xenopus tropicalis and studied their expression patterns during embryonic development. The Xenopus LAP proteins show a conserved domain structure that is similar to their homologs in other vertebrates. In Xenopus embryos, these genes were detected in animal cap cells at the early gastrula stage. At later stages of development, they were widely expressed in epithelial tissues that are highly polar in nature, including the neural epithelia, optic and otic vesicles, and in the pronephros. These data suggest that the roles of the Xenopus LAP genes in the control of cell polarity and morphogenesis are conserved during early development. Erbin and lano show similar expression patterns in the developing head, suggesting potential functional interactions between the two molecules in vivo
收录类别SCI
资助信息This work was supported by the Key State Research Program from Ministry of Science and Technology of China (Grant No. 2007CB947201) and the State Key Laboratory of Genetic Resources and Evolution.
语种英语
公开日期2012-03-16
内容类型期刊论文
源URL[http://159.226.149.42:8088/handle/353002/6867]  
专题昆明动物研究所_发育生物学
昆明动物研究所_遗传资源与进化国家重点实验室
作者单位1.Core Facility of Genetically Engineered Mice, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China
2.CAS-Max Planck Junior Scientist Group, State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China
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GB/T 7714
Yang QT,Lv XY,Kong QH,et al. Dynamic expression of the LAP family of genes during early development of Xenopus tropicalis[J]. SCIENCE CHINA-LIFE SCIENCES,2011,54(10):897-903.
APA Yang QT,Lv XY,Kong QH,Li CC,Zhou Q[*],&Mao BY[*].(2011).Dynamic expression of the LAP family of genes during early development of Xenopus tropicalis.SCIENCE CHINA-LIFE SCIENCES,54(10),897-903.
MLA Yang QT,et al."Dynamic expression of the LAP family of genes during early development of Xenopus tropicalis".SCIENCE CHINA-LIFE SCIENCES 54.10(2011):897-903.
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