A short peptide from frog skin accelerates diabetic wound healing

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 动物毒素室

	A short peptide from frog skin accelerates diabetic wound healing
	Liu H 1,2; Duan ZL 1,2; Tang J 1,2; Lv QM 1; Rong MQ 1; Lai R[*]1
刊名	FEBS JOURNAL
	2014
卷号	281 期号:20 页码:4633-4643
关键词	amphibian angiogenesis anti-inflammatory diabetic wounds wound healing
通讯作者	rlai@mail.kiz.ac.cn
合作状况	其它
英文摘要	elayed wound healing will result in the development of chronic wounds in some diseases, such as diabetes. Amphibian skins possess excellent wound-healing ability and represent a resource for prospective wound-healing promoting compounds. A potential wound-healing promoting peptide (CW49; amino acid sequence APFRMGICTTN) was identified from the frog skin of Odorranagrahami. It promotes wound healing in a murine model with a full-thickness dermal wound in both normal and diabetic animals. In addition to its strong angiogenic ability with respect to the upregulation of some angiogenic proteins, CW49 also showed a significant anti-inflammatory effect in diabetic wounds, which was very important for healing chronic wounds. CW49 had little effect on re-epithelialization, resulting in no significant effect on wound closure rate compared to a vehicle control. Altogether, this indicated that CW49 might accelerate diabetic wound healing by promoting angiogenesis and preventing any excessive inflammatory response. Considering its favorable traits as a small peptide that significantly promotes angiogenesis, CW49 might be an excellent candidate or template for the development of a drug for use in the treatment of diabetic wounds.
收录类别	SCI
资助信息	This work was supported by the Ministry of Science and Technology (2010CB529800, 2013CB911300), National Natural Science Foundation (31025025, 31025025, U1132601, U1302221, 31200590) and Yun- nan Province (2011CI139, 2012BC009).
语种	英语
WOS记录号	WOS:000343918500007
公开日期	2014-10-29
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/8158]
专题	昆明动物研究所_动物毒素室昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位	1.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Yunnan, China 2.Graduate University of Chinese Academy of Sciences, Beijing, China
推荐引用方式 GB/T 7714	Liu H,Duan ZL,Tang J,et al. A short peptide from frog skin accelerates diabetic wound healing[J]. FEBS JOURNAL,2014,281(20):4633-4643.
APA	Liu H,Duan ZL,Tang J,Lv QM,Rong MQ,&Lai R[*].(2014).A short peptide from frog skin accelerates diabetic wound healing.FEBS JOURNAL,281(20),4633-4643.
MLA	Liu H,et al."A short peptide from frog skin accelerates diabetic wound healing".FEBS JOURNAL 281.20(2014):4633-4643.