The cathelicidin-like peptide derived from panda genome is a potential antimicrobial peptide

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	The cathelicidin-like peptide derived from panda genome is a potential antimicrobial peptide
	Yan XW 1; Zhong J 3; Liu H 2,4; Liu CB 2,4; Zhang KY 1; Lai R[*]1,2
刊名	GENE
	2012
卷号	492 期号:2 页码:368-374
关键词	Cathelicidic Antimicrobial peptides Panda Innate immunity
通讯作者	rlai72@njau.edu.cn
合作状况	其它
英文摘要	A novel cathelicidin-like antimicrobial peptide was identified by mining genome of panda. This peptide (cathelicidin-AM) was synthesized. It showed potential antimicrobial activities against wide spectrum of microorganisms including Gram-negative and -positive bacteria, and fungi. It had similar antimicrobial abilities against both standard and clinically isolated drug-resistant strains. Cathelicidin-AM could rapidly exert its antibacterial activities. It just took less than I h to kill all Staphylococcus sciuri at the concentration of 2, 4 or 10 times of minimal inhibitory concentration (MIC) while clindamycin took 6 h. Transmission electron microscopy (TEM) and scanning electron microscopy (SEM) analysis indicated that cathelicidin-AM killed bacteria by directly affecting bacterial cell wall and membrane. Phylogenetic analysis revealed that the panda cathelicidin had the nearest evolution relationship with dog cathelicidin. The current work provides a novel cathelicidin-like peptide with strong antimicrobial abilities
收录类别	SCI
资助信息	This work was supported by the Chinese National Natural Science Foundation (31070701, 31000962, 31025025), the Ministry of Science and Technology (2010CB529800, 2009ZX09103-1/091, 2011ZX09102- 002-10) and the Ministry of Agriculture (2009ZX08009-159B).
语种	英语
WOS记录号	WOS:000299987900006
公开日期	2012-03-20
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/353002/6884]
专题	昆明动物研究所_动物毒素室昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位	1.Life Sciences College of Nanjing Agricultural University, Nanjing 210095, Jiangsu, China 2.Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China 3.Nanjing Maternal and Child Health Hospital, No. 123 Tianfeixiang, Nanjing, 210004, China 4.Graduate School of the Chinese Academy of Sciences, Beijing100009, China
推荐引用方式 GB/T 7714	Yan XW,Zhong J,Liu H,et al. The cathelicidin-like peptide derived from panda genome is a potential antimicrobial peptide[J]. GENE,2012,492(2):368-374.
APA	Yan XW,Zhong J,Liu H,Liu CB,Zhang KY,&Lai R[*].(2012).The cathelicidin-like peptide derived from panda genome is a potential antimicrobial peptide.GENE,492(2),368-374.
MLA	Yan XW,et al."The cathelicidin-like peptide derived from panda genome is a potential antimicrobial peptide".GENE 492.2(2012):368-374.