Nickel-Catalyzed Reductive Cross-Coupling of (Hetero)Aryl Iodides with Fluorinated Secondary Alkyl Bromides

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	Nickel-Catalyzed Reductive Cross-Coupling of (Hetero)Aryl Iodides with Fluorinated Secondary Alkyl Bromides
	Li XF(李学飞)1; Feng Z(冯璋)1; Jiang ZX(江中兴)1; Zhang XG(张新刚)1
刊名	Org. Lett.
	2015
卷号	17 期号:22 页码:5570-5573
其他题名	镍催化下(杂)芳基碘代物与氟代二级溴代烷烃的还原偶联反应
通讯作者	江中兴 ; 张新刚
英文摘要	A mild and efficient nickel-catalyzed reductive cross-coupling between fluorinated secondary alkyl bromides and (hetero)aryl iodides is described. The use of FeBr2 as an additive successfully overcomes the hydrodebromination and beta-fluorine elimination of fluorinated substrates and allows the efficient synthesis of a wide range of trifluoromethyl and difluoroalkyl containing aliphatic compounds with a fluoroalkyl substituted tertiary carbon center. The notable features of this protocol are the synthetic and operational simplicity without preparation of moisture sensitive organometallic reagents and excellent functional group compatibility, even toward active proton containing substrates.
学科主题	氟化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1021/acs.orglett.5b02716
语种	英语
WOS记录号	WOS:000365462900015
内容类型	期刊论文
源URL	[http://ir.sioc.ac.cn/handle/331003/39763]
专题	上海有机化学研究所_中科院有机氟化学重点实验室
作者单位	1.武汉大学 2.中科院上海有机化学研究所, 有机氟化学重点实验室
推荐引用方式 GB/T 7714	Li XF,Feng Z,Jiang ZX,et al. Nickel-Catalyzed Reductive Cross-Coupling of (Hetero)Aryl Iodides with Fluorinated Secondary Alkyl Bromides[J]. Org. Lett.,2015,17(22):5570-5573.
APA	李学飞,冯璋,江中兴,&张新刚.(2015).Nickel-Catalyzed Reductive Cross-Coupling of (Hetero)Aryl Iodides with Fluorinated Secondary Alkyl Bromides.Org. Lett.,17(22),5570-5573.
MLA	李学飞,et al."Nickel-Catalyzed Reductive Cross-Coupling of (Hetero)Aryl Iodides with Fluorinated Secondary Alkyl Bromides".Org. Lett. 17.22(2015):5570-5573.