Difluorocarbene-Derived Trifluoromethylthiolation and [F-18]Trifluoromethylthiolation of Aliphatic Electrophiles

CORC > 上海有机化学研究所 > 中国科学院上海有机化学研究所 > 中科院有机氟化学重点实验室

	Difluorocarbene-Derived Trifluoromethylthiolation and [F-18]Trifluoromethylthiolation of Aliphatic Electrophiles
	Zheng J(郑剑)1; Wang L(王璐)1; Lin JH(林锦鸿)1; Xiao JC(肖吉昌)1; Liang H(梁欢)1
刊名	Angew. Chem.-Int. Edit.
	2015
卷号	54 期号:45 页码:13236-13240
其他题名	源于二氟卡宾的脂肪族亲电物种的三氟甲硫基化及氟-18标记
通讯作者	肖吉昌 ; 梁欢
英文摘要	The first trifluoromethylthiolation and [F-18]trifluoromethylthiolation of alkyl electrophiles with insitu generated difluorocarbene in the presence of elemental sulfur and external (radioactive) fluoride ion is described. This transition-metal-free approach is high yielding, compatible with a variety of functional groups, and operated under mild reaction conditions. The conceptual advantage of this exogenous-fluoride-mediated transformation enables unprecedented syntheses of [F-18]CF3S-labeled molecules from most commonly used [F-18]fluoride ions. The rapid radiochemical reaction time (1min) and high functional-group tolerance allow access to a variety of aliphatic [F-18]CF3S compounds in high yields.
学科主题	氟化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1002/anie.201505446
语种	英语
WOS记录号	WOS:000363691500011
内容类型	期刊论文
源URL	[http://ir.sioc.ac.cn/handle/331003/39752]
专题	上海有机化学研究所_中科院有机氟化学重点实验室
作者单位	1.中科院上海有机化学研究所, 有机氟化学重点实验室 2.美国哈佛大学
推荐引用方式 GB/T 7714	Zheng J,Wang L,Lin JH,et al. Difluorocarbene-Derived Trifluoromethylthiolation and [F-18]Trifluoromethylthiolation of Aliphatic Electrophiles[J]. Angew. Chem.-Int. Edit.,2015,54(45):13236-13240.
APA	郑剑,王璐,林锦鸿,肖吉昌,&梁欢.(2015).Difluorocarbene-Derived Trifluoromethylthiolation and [F-18]Trifluoromethylthiolation of Aliphatic Electrophiles.Angew. Chem.-Int. Edit.,54(45),13236-13240.
MLA	郑剑,et al."Difluorocarbene-Derived Trifluoromethylthiolation and [F-18]Trifluoromethylthiolation of Aliphatic Electrophiles".Angew. Chem.-Int. Edit. 54.45(2015):13236-13240.