Squaramide-Catalyzed Synthesis of Enantioenriched Spirocyclic Oxindoles via Ketimine Intermediates with Multiple Active Sites

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	Squaramide-Catalyzed Synthesis of Enantioenriched Spirocyclic Oxindoles via Ketimine Intermediates with Multiple Active Sites
	Sun QS(孙强盛)1; Zhu H(朱华)1; Chen YJ(陈永剑)1; Yang XD(杨笑迪)1; Sun XW(孙兴文)1; Lin GQ(林国强)1
刊名	Angew. Chem.-Int. Edit.
	2015
卷号	54 期号:45 页码:13253-13257
其他题名	螺酰胺催化的通过形成具有的活化位点的酮亚胺中间体构建高对映选择性的螺环羟吲哚
通讯作者	孙兴文
英文摘要	A new method for the construction of five-membered spirocyclic oxindoles is based on a Michael-Mannich cascade reaction of a ketimine intermediated catalyzed by a bifunctional quinine-derived squaramide. The desired products were obtained in excellent yields (up to 94%) and stereoselectivities (up to >20:1 d.r., >99% ee). A scaled-up variant also proceeded smoothly showing that the one-pot reaction might find application in the synthesis of bioactive-compound libraries.
学科主题	天然产物有机化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1002/anie.201506206
语种	英语
WOS记录号	WOS:000363691500015
内容类型	期刊论文
源URL	[http://ir.sioc.ac.cn/handle/331003/39807]
专题	上海有机化学研究所_中科院天然产物有机化学重点实验室
作者单位	1.复旦大学 2.中科院上海有机化学研究所
推荐引用方式 GB/T 7714	Sun QS,Zhu H,Chen YJ,et al. Squaramide-Catalyzed Synthesis of Enantioenriched Spirocyclic Oxindoles via Ketimine Intermediates with Multiple Active Sites[J]. Angew. Chem.-Int. Edit.,2015,54(45):13253-13257.
APA	孙强盛,朱华,陈永剑,杨笑迪,孙兴文,&林国强.(2015).Squaramide-Catalyzed Synthesis of Enantioenriched Spirocyclic Oxindoles via Ketimine Intermediates with Multiple Active Sites.Angew. Chem.-Int. Edit.,54(45),13253-13257.
MLA	孙强盛,et al."Squaramide-Catalyzed Synthesis of Enantioenriched Spirocyclic Oxindoles via Ketimine Intermediates with Multiple Active Sites".Angew. Chem.-Int. Edit. 54.45(2015):13253-13257.