Characterizing ion mobility and collision cross section of fatty acids using electrospray ion mobility mass spectrometry

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	Characterizing ion mobility and collision cross section of fatty acids using electrospray ion mobility mass spectrometry
	Zhang F(张芳)1; Guo S(郭甦)1; Zhang MY(张曼玉)1; Zhang ZX(张之旭)1; Guo YL(郭寅龙)1
刊名	J. Mass Spectrom.
	2015
卷号	50 期号:7 页码:906-913
其他题名	电喷雾离子迁移质谱表征脂肪酸的离子迁移和碰撞截面
通讯作者	郭寅龙
英文摘要	This study investigated the ion mobility (IM) and the collision cross section (CCS) of fatty acids (FAs) using electrospray IM MS. The IM analysis of 18 FA ions showed intriguing differences among the saturated FAs, monounsaturated FAs, multi-unsaturated FAs, and cis-isomer/trans-isomer with respect to the aliphatic tail chains. The length of aliphatic tail chain present in the ion structures had a strong influence on the differentiation of drift, while the number of double bond showed a weaker influence. The tiny drift differences between cis-isomer and trans-isomer were also observed. In the CCS measurements, two internal standards were involved in the mobility calibration and accuracy estimation. It insured our empirical CCS values were of high experimental precision (+/- 0.35% or better) and accuracy (+/- 0.25% or better). Moreover, the mass-to-charge ratio (m/z) - mobility plots obtained by ion mobility spectrometry with mass spectrometry analysis of FAs - was used to investigate the structural relationship between the molecules. Each series of FAs sharing a similar structure was aligned in the linear plot. Finally, the developed procedure was applied to the determination of FAs in rat adipose tissues, and it allowed the presence of 13 FAs to be confirmed with their exact masses and CCS values. These studies reveal the direct relationship between the behaviors in IM and the molecular structures and thus may provide further validations to the FA identification process. Copyright (C) 2015 John Wiley & Sons, Ltd.
学科主题	分析化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1002/jms.3600
语种	英语
WOS记录号	WOS:000359273200005
内容类型	期刊论文
源URL	[http://ir.sioc.ac.cn/handle/331003/39692]
专题	上海有机化学研究所_分析化学研究室
作者单位	1.中科院上海有机化学研究所, 上海质谱中心 2.复旦大学 3.安捷伦科技(中国)有限公司
推荐引用方式 GB/T 7714	Zhang F,Guo S,Zhang MY,et al. Characterizing ion mobility and collision cross section of fatty acids using electrospray ion mobility mass spectrometry[J]. J. Mass Spectrom.,2015,50(7):906-913.
APA	张芳,郭甦,张曼玉,张之旭,&郭寅龙.(2015).Characterizing ion mobility and collision cross section of fatty acids using electrospray ion mobility mass spectrometry.J. Mass Spectrom.,50(7),906-913.
MLA	张芳,et al."Characterizing ion mobility and collision cross section of fatty acids using electrospray ion mobility mass spectrometry".J. Mass Spectrom. 50.7(2015):906-913.