Fabrication of a mercaptoacetic acid pillar[5]arene assembled nanochannel: a biomimetic gate for mercury poisoning

	Fabrication of a mercaptoacetic acid pillar[5]arene assembled nanochannel: a biomimetic gate for mercury poisoning
	Zhang, Fan 1; Ma, Junkai 1; Sun, Yue 1; Boussouar, Imene 1; Tian, Demei 1; Li, Haibing 1,2; Jiang, Lei 2
刊名	CHEMICAL SCIENCE
	2016
卷号	7 期号:5 页码:3227-3233
英文摘要	Mercury ion binding blocks potassium ion channels, which leads to toxicity in vivo. It is challenging to design a simple and efficient artificial system to mimic the sophisticated biological process of mercury poisoning. Herein, based on biomimetic strategies, a tunable mercury(II) ion-gate modulated by mercaptoacetic acid-pillar[5] arene (MAP5) is reported. By virtue of the unique design of the host-guest competition, potassium ion transport can actualize the reversible switching between "on" and "off" in the absence and presence of mercury ions. Moreover, the MAP5-immobilized nanochannel is highly effective at distinguishing Hg2+ from other metal ions and can be used to detect Hg2+ and act as an excellent and robust gate valve for developing integrated circuits and nanoelectronic logic devices. This study paves a new way for better understanding the physiological phenomenon of mercury toxicity and shows great promise for biomedical research.
收录类别	SCI
语种	英语
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/36038]
专题	化学研究所_有机固体实验室
作者单位	1.Cent China Normal Univ, Minist Educ, Coll Chem, Key Lab Pesticide & Chem Biol CCNU, Wuhan 430079, Peoples R China 2.Chinese Acad Sci, Inst Chem, Key Lab Organ Solids, BNLMS, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Fan,Ma, Junkai,Sun, Yue,et al. Fabrication of a mercaptoacetic acid pillar[5]arene assembled nanochannel: a biomimetic gate for mercury poisoning[J]. CHEMICAL SCIENCE,2016,7(5):3227-3233.
APA	Zhang, Fan.,Ma, Junkai.,Sun, Yue.,Boussouar, Imene.,Tian, Demei.,...&Jiang, Lei.(2016).Fabrication of a mercaptoacetic acid pillar[5]arene assembled nanochannel: a biomimetic gate for mercury poisoning.CHEMICAL SCIENCE,7(5),3227-3233.
MLA	Zhang, Fan,et al."Fabrication of a mercaptoacetic acid pillar[5]arene assembled nanochannel: a biomimetic gate for mercury poisoning".CHEMICAL SCIENCE 7.5(2016):3227-3233.