Cationic Conjugated Polymers-Induced Quorum Sensing of Bacteria Cells

	Cationic Conjugated Polymers-Induced Quorum Sensing of Bacteria Cells
	Zhang, Pengbo; Lu, Huan; Chen, Hui; Zhang, Jiangyan; Liu, Libing; Lv, Fengting; Wang, Shu
刊名	ANALYTICAL CHEMISTRY
	2016-03-15
卷号	88 期号:6 页码:2985-2988
英文摘要	Bacteria quorum sensing (QS) has attracted significant interest for understanding cell cell communication and regulating biological functions. In this work, we demonstrate that water-soluble cationic conjugated polymers (PFP-G2) can interact with bacteria to form aggregates through electrostatic interactions. With bacteria coated in the aggregate, PFP-G2 can induce the bacteria QS system and prolong the time duration of QS signal molecules (autoinducer-2 (AI-2)) production. The prolonged AI-2 can bind with specific protein and continuously regulate downstream gene expression. Consequently, the bacteria show a higher survival rate against antibiotics,: resulting in decreased antimicrobial susceptibility. Also, AI-2 induced by PFP-G2 can stimulate 55.54 +/- 12.03% more biofilm in E. coli. This method can be used to understand cell cell communication and regulate biological functions, such as the production of signaling molecules, antibiotics, other microbial metabolites, and even virulence.
收录类别	SCI
语种	英语
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/35926]
专题	化学研究所_有机固体实验室
作者单位	Chinese Acad Sci, Inst Chem, Key Lab Organ Solids, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Pengbo,Lu, Huan,Chen, Hui,et al. Cationic Conjugated Polymers-Induced Quorum Sensing of Bacteria Cells[J]. ANALYTICAL CHEMISTRY,2016,88(6):2985-2988.
APA	Zhang, Pengbo.,Lu, Huan.,Chen, Hui.,Zhang, Jiangyan.,Liu, Libing.,...&Wang, Shu.(2016).Cationic Conjugated Polymers-Induced Quorum Sensing of Bacteria Cells.ANALYTICAL CHEMISTRY,88(6),2985-2988.
MLA	Zhang, Pengbo,et al."Cationic Conjugated Polymers-Induced Quorum Sensing of Bacteria Cells".ANALYTICAL CHEMISTRY 88.6(2016):2985-2988.