Self-Aggregation, Antibacterial Activity, and Mildness of Cyclodextrin/Cationic Trimeric Surfactant Complexes

CORC > 化学研究所 > 中国科学院化学研究所 > 胶体、界面与化学热力学实验室

	Self-Aggregation, Antibacterial Activity, and Mildness of Cyclodextrin/Cationic Trimeric Surfactant Complexes
	Zhou, Chengcheng 1,3; Wang, Dong 4; Cao, Meiwen 4; Chen, Yao 1,3; Liu, Zhang 1,3; Wu, Chunxian 1,3; Xu, Hai 4; Wang, Shu 2; Wang, Yilin 1,3
刊名	ACS APPLIED MATERIALS & INTERFACES
	2016-11-16
卷号	8 期号:45 页码:30811-30823
关键词	cyclodextrin cationic trimeric surfactant aggregation behavior antimicrobial activities mildness
英文摘要	Despite efficacious antimicrobial activity, cationic oligomeric surfactants show strong skin irritation potential due to their larger cationic charge numbers and multiple hydrophobic chains. This work reports that the incorporation of alpha-, beta-, and gamma-CDs with different cavity sizes can effectively improve the mildness of cationic ammonium trimeric surfactant DTAD with a star-shaped spacer while maintaining its high antibacterial activity. On the basis of the different cavity sizes of CDs and the asymmetry in the spacer of DTAD, the CD/DTAD mixtures form alpha-CD@DTAD, 2 alpha-CD@DTAD, beta-CD@DTAD, and gamma-CD@DTAD complexes. Compared to DTAD, these CD/DTAD complexes show much stronger self-assembly ability with much lower critical aggregation concentrations (CAC) and form more diverse aggregates with reduced zeta potential. Just above their CACs, the CD/DTAD complexes form vesicles or solid spherical aggregates of similar to 50 nm and then transform into small micelles of similar to 10 nm as the concentration increases. The strong self-assembly ability and the multiple sites of hydrogen bonds of the CD/DTAD complexes endow them with high antibacterial activity against E. coli, showing a very low minimum inhibitory concentration (2.22-2.48 mu M) comparable to that of DTAD. In particular, the addition of CDs significantly reduces the abilities of DTAD in solubilizing zein (a skin model protein) and in binding with zein, and the mildness decreases in the order of 2 alpha-CD@DTAD > beta-CD@DTAD > gamma-CD@DTAD > alpha-CD@DTAD. This tendency depends on their different self-assembling structures, and the formation of vesicles is approved to be in favor of the improvement of the mildness.
收录类别	SCI
语种	英语
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/35684]
专题	化学研究所_胶体、界面与化学热力学实验室
作者单位	1.Chinese Acad Sci, Inst Chem, BNLMS, Key Lab Colloid & Interface Sci, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Chem, Key Lab Organ Solids, BNLMS, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.China Univ Petr East China, Ctr Bioengn & Biotechnol, Qingdao 266580, Peoples R China
推荐引用方式 GB/T 7714	Zhou, Chengcheng,Wang, Dong,Cao, Meiwen,et al. Self-Aggregation, Antibacterial Activity, and Mildness of Cyclodextrin/Cationic Trimeric Surfactant Complexes[J]. ACS APPLIED MATERIALS & INTERFACES,2016,8(45):30811-30823.
APA	Zhou, Chengcheng.,Wang, Dong.,Cao, Meiwen.,Chen, Yao.,Liu, Zhang.,...&Wang, Yilin.(2016).Self-Aggregation, Antibacterial Activity, and Mildness of Cyclodextrin/Cationic Trimeric Surfactant Complexes.ACS APPLIED MATERIALS & INTERFACES,8(45),30811-30823.
MLA	Zhou, Chengcheng,et al."Self-Aggregation, Antibacterial Activity, and Mildness of Cyclodextrin/Cationic Trimeric Surfactant Complexes".ACS APPLIED MATERIALS & INTERFACES 8.45(2016):30811-30823.