Intercellular Connections Related to Cell-Cell Crosstalk Specifically Recognized by an Aptamer

	Intercellular Connections Related to Cell-Cell Crosstalk Specifically Recognized by an Aptamer
	Zhang, Nan 1,2; Bing, Tao 1; Shen, Luyao 1,2; Song, Rusheng 1,2; Wang, Linlin 1,2; Liu, Xiangjun 1; Liu, Meirong 1; Li, Juan 3,4,5; Tan, Weihong 3,4,5; Shangguan, Dihua 1
刊名	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
	2016-03-14
卷号	55 期号:12 页码:3914-3918
关键词	aptamers cell communication fluorescent probes intercellular connections tunneling nanotubes
英文摘要	Intercellular connections are an important pathway for cell-cell crosstalk. However, their formation mechanism and functions are far from being understood. The lack of molecular probes hampers the research in this area. Herein, we report a kind of intercellular connection that is specifically recognized by aptamer M17A2 generated by cell-SELEX against MCF-7R cells. These connections have different morphologies, but have the same skeleton composed of F-actin. The long filamentous connections were identified to be tunneling nanotubes (TNTs), a recently discovered cell-cell communication route. These connections could be built not only between MCF-7R cells, but also from MCF-7R to other cells after co-culture. Proteins could be transported between cells through these connections, suggesting their cell communication function. Aptamer M17A2 shows the potential to act as a new probe for investigating this kind of intercellular connection, as well as for studying cell-cell communication.
收录类别	SCI
语种	英语
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/35944]
专题	化学研究所_活体分析化学实验室
作者单位	1.Chinese Acad Sci, Inst Chem, Key Lab Analyt Chem Living Biosyst, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Univ Florida, Ctr Res Bio Nano Interface, Hlth Canc Ctr, Genet Inst,McKnight Brain Inst, Gainesville, FL 32611 USA 4.Hunan Univ, Coll Biol, State Key Lab Chemo Biosensing & Chemometr, Mol Sci & Biomed Lab, Changsha 410082, Hunan, Peoples R China 5.Hunan Univ, Coll Chem & Chem Engn, Changsha 410082, Hunan, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Nan,Bing, Tao,Shen, Luyao,et al. Intercellular Connections Related to Cell-Cell Crosstalk Specifically Recognized by an Aptamer[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2016,55(12):3914-3918.
APA	Zhang, Nan.,Bing, Tao.,Shen, Luyao.,Song, Rusheng.,Wang, Linlin.,...&Shangguan, Dihua.(2016).Intercellular Connections Related to Cell-Cell Crosstalk Specifically Recognized by an Aptamer.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,55(12),3914-3918.
MLA	Zhang, Nan,et al."Intercellular Connections Related to Cell-Cell Crosstalk Specifically Recognized by an Aptamer".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 55.12(2016):3914-3918.