Kinesin-1 inhibits the aggregation of amyloid-beta peptide as detected by fluorescence cross-correlation spectroscopy

	Kinesin-1 inhibits the aggregation of amyloid-beta peptide as detected by fluorescence cross-correlation spectroscopy
	Zheng, Yanpeng 1; Tian, Shijun 1; Peng, Xianglei 1; Yang, Jingfa 2; Fu, Yuanhui 1; Jiao, Yueying 1; Zhao, Jiang 2; He, Jinsheng 1; Hong, Tao 1,3
刊名	FEBS LETTERS
	2016-04-01
卷号	590 期号:7 页码:1028-1037
关键词	Alzheimer's disease amyloid beta fluorescence cross-correlation spectroscopy kinesin-1
英文摘要	Although the exact etiology and pathogenesis of Alzheimer's disease (AD) are still unclear, amyloid-beta (A beta) generated by the proteolytic processing of amyloid-b precursor protein (APP) aggregate to form toxic amyloid species. Kinesin-1 is the first identified ATP-dependent axonal transport motor protein that has been proven to affect A beta generation and deposition. In this paper, we applied dual-color fluorescence cross-correlation spectroscopy (DC-FCCS) to investigate the direct interaction of A beta with kinesin-1 at the single-molecule fluorescence level in vitro. The results showed that two kinds of enhanced green fluorescent protein (EGFP)-tagged kinesin light-chain subunits of kinesin-1(KLCs), KLC-E and E-KLC inhibited the aggregation of A beta over a period of time, providing additional insight into the mechanism of axonal transport deficits in AD.
收录类别	SCI
语种	英语
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/36002]
专题	化学研究所_高分子物理与化学实验室
作者单位	1.Beijing Jiaotong Univ, Coll Life Sci & Bioengn, Beijing 100044, Peoples R China 2.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 3.Chinese Ctr Dis Control & Prevent, Inst Viral Dis Control & Prevent, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Zheng, Yanpeng,Tian, Shijun,Peng, Xianglei,et al. Kinesin-1 inhibits the aggregation of amyloid-beta peptide as detected by fluorescence cross-correlation spectroscopy[J]. FEBS LETTERS,2016,590(7):1028-1037.
APA	Zheng, Yanpeng.,Tian, Shijun.,Peng, Xianglei.,Yang, Jingfa.,Fu, Yuanhui.,...&Hong, Tao.(2016).Kinesin-1 inhibits the aggregation of amyloid-beta peptide as detected by fluorescence cross-correlation spectroscopy.FEBS LETTERS,590(7),1028-1037.
MLA	Zheng, Yanpeng,et al."Kinesin-1 inhibits the aggregation of amyloid-beta peptide as detected by fluorescence cross-correlation spectroscopy".FEBS LETTERS 590.7(2016):1028-1037.