Synthesis and Properties of Hemostatic and Bacteria-Responsive in Situ Hydrogels for Emergency Treatment in Critical Situations

	Synthesis and Properties of Hemostatic and Bacteria-Responsive in Situ Hydrogels for Emergency Treatment in Critical Situations
	Bu, Yazhong 1; Zhang, Licheng 2; Liu, Jianheng 2; Zhang, Lihai 2; Li, Tongtong 2; Shen, Hong 1; Wang, Xing 1; Yang, Fei 1; Tang, Peifu 2; Wu, Decheng 1
刊名	ACS APPLIED MATERIALS & INTERFACES
	2016-05-25
卷号	8 期号:20 页码:12674-12683
关键词	PEG hydrogels hemostasis antibacteria pH-responsive
英文摘要	Immediate hemorrhage control and infection prevention are pivotal for saving lives in critical situations such as battlefields, natural disasters, traffic accidents, and so on. In situ hydrogels are promising candidates, but their mechanical strength is often not strong enough for use in critical situations. In this study, we constructed three hydrogels with different amounts of Schiff-base moieties from 4-arm-PEGNH2, 4-arm-PEG-NHS, and 4-arm-PEG-CHO in which vancomycin was incorporated as an antimicrobial agent. The hydrogels possess porous structures, excellent mechanical strength, and high swelling ratio. The cytotoxicity studies indicated that the composite hydrogel systems possess good biocompatibility. The Schiff bases incorporated improve the adhesiveness and endow the hydrogels with bacteria-sensitivity. The in vivo hemostatic and antimicrobial experiments on rabbits and pigs demonstrated that the hydrogels are able to aid in rapid hemorrhage control and infection prevention. In summary, vancomycin-loaded hydrogels may be hemostatic and antibacterial materials for first aid treatment of the wounded in critical situations.excellent candidates as
收录类别	SCI
语种	英语
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/35765]
专题	化学研究所_高分子物理与化学实验室
作者单位	1.Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 2.Chinese Peoples Liberat Army Gen Hosp, Dept Orthopaed, Beijing 100853, Peoples R China
推荐引用方式 GB/T 7714	Bu, Yazhong,Zhang, Licheng,Liu, Jianheng,et al. Synthesis and Properties of Hemostatic and Bacteria-Responsive in Situ Hydrogels for Emergency Treatment in Critical Situations[J]. ACS APPLIED MATERIALS & INTERFACES,2016,8(20):12674-12683.
APA	Bu, Yazhong.,Zhang, Licheng.,Liu, Jianheng.,Zhang, Lihai.,Li, Tongtong.,...&Wu, Decheng.(2016).Synthesis and Properties of Hemostatic and Bacteria-Responsive in Situ Hydrogels for Emergency Treatment in Critical Situations.ACS APPLIED MATERIALS & INTERFACES,8(20),12674-12683.
MLA	Bu, Yazhong,et al."Synthesis and Properties of Hemostatic and Bacteria-Responsive in Situ Hydrogels for Emergency Treatment in Critical Situations".ACS APPLIED MATERIALS & INTERFACES 8.20(2016):12674-12683.