Synthesis of beta-Difluoroalkylated Acrylonitriles in the Presence of Copper Powder | |
He, Yu-Tao1; Li, Lian-Hua1; Wang, Qiang1; Wu WS(吴王锁)2; Liang YM(梁永民)1,3 | |
刊名 | Organic Letters |
2016 | |
卷号 | 18期号:19页码:5158-5161 |
ISSN号 | 1523-7060 |
通讯作者 | 梁永民 |
英文摘要 | A highly regio- and stereoselective copper-mediated cyanodifluoroalkylation of alkynes with ethyl difluoroiodoacetate and trimethylsilyl cyanide (TMSCN) is described. The three-component coupling reaction provides straightforward access to a variety of useful difluoroalkyl-substituted acrylonitriles. The introduction of the nitrile unit is of great importance in drug discovery for the modification of this fragment. Preliminary mechanistic investigations indicate that a vinyl iodide intermediate and a difluoroalkyl radical might be involved in this transformation. |
学科主题 | 材料科学与物理化学 |
收录类别 | SCI |
资助信息 | the National Natural Science Foundation (NSF 21272101;21372074;21472073);the Fundamental Research Funds for the Central Universities (lzujbky-2014-243;lzujbky-2014-194);the "111" Project (J1103307);Program for Changjiang Scholars, and Innovative Research Team in University (IRT1138) |
语种 | 英语 |
WOS记录号 | WOS:000385053900102 |
内容类型 | 期刊论文 |
源URL | [http://210.77.64.217/handle/362003/21038] |
专题 | 兰州化学物理研究所_固体润滑国家重点实验室 |
作者单位 | 1.Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China 2.Lanzhou Univ, Sch Nucl Sci & Technol, Radiochem Lab, Lanzhou 730000, Peoples R China 3.Chinese Acad Sci, State Key Lab Solid Lubricat, Lanzhou Inst Chem Phys, Lanzhou 730000, Peoples R China |
推荐引用方式 GB/T 7714 | He, Yu-Tao,Li, Lian-Hua,Wang, Qiang,et al. Synthesis of beta-Difluoroalkylated Acrylonitriles in the Presence of Copper Powder[J]. Organic Letters,2016,18(19):5158-5161. |
APA | He, Yu-Tao,Li, Lian-Hua,Wang, Qiang,Wu WS,&Liang YM.(2016).Synthesis of beta-Difluoroalkylated Acrylonitriles in the Presence of Copper Powder.Organic Letters,18(19),5158-5161. |
MLA | He, Yu-Tao,et al."Synthesis of beta-Difluoroalkylated Acrylonitriles in the Presence of Copper Powder".Organic Letters 18.19(2016):5158-5161. |
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