Depressive-like history alters persistent pain behavior in rats: Opposite contribution of frontal cortex and amygdala implied

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	Depressive-like history alters persistent pain behavior in rats: Opposite contribution of frontal cortex and amygdala implied
	Qi, Wei-Jing; Wang, Wei; Wang, Ning; Wang, Jin-Yan; Luo, Fei; Wang JY; Luo F
刊名	Psych Journal
	2013
通讯作者邮箱	wangjy@psych.ac.cn ; luof@psych.ac.cn
卷号	2 期号:2 页码:133-145
关键词	amygdala depression medial prefrontal cortex pain
ISSN号	2046-0260
通讯作者	Wang JY ; Luo F
产权排序	1
英文摘要	Numerous studies have shown that pain perception is strongly influenced by depression. However, very few studies have examined whether pain perception is altered in the remission period of depression, and what role the fronto-limbic circuits may play in the behavioral changes associated with remission. Using an unpredictable chronic mild stress (UCMS) animal model of depression, the present study investigated pain-related behaviors in rats with prior exposure to a UCMS stimulus. The gamma-aminobutyric acid (GABA)A receptor agonist muscimol was microinjected bilaterally into the basolateral amygdala (BLA) and the medial prefrontal cortex (mPFC) to examine the modulation of pain by these brain regions in the recovery state. Rats with a depression-like history displayed increased ongoing pain behavior in the formalin test, although their thermal pain thresholds were unchanged. Intra-BLA muscimol during the recovery phase dramatically decreased formalin-induced pain behavior and also significantly increased rats' sucrose preference. By contrast, in the mPFC, muscimol produced the opposite effect, suggesting different, perhaps opposing, roles of the BLA and mPFC in mediating the influence of prior UCMS exposure on pain perception. Taken together, these results demonstrated that a depressive experience may cause long-term alterations in limbic circuit excitability and thus lead to long-lasting changes in pain perception.
学科主题	生理心理学/生物心理学
收录类别	其他
语种	英语
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/20724]
专题	心理研究所_中国科学院心理健康重点实验室
通讯作者	Wang JY; Luo F
作者单位	Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
推荐引用方式 GB/T 7714	Qi, Wei-Jing,Wang, Wei,Wang, Ning,et al. Depressive-like history alters persistent pain behavior in rats: Opposite contribution of frontal cortex and amygdala implied[J]. Psych Journal,2013,2(2):133-145.
APA	Qi, Wei-Jing.,Wang, Wei.,Wang, Ning.,Wang, Jin-Yan.,Luo, Fei.,...&Luo F.(2013).Depressive-like history alters persistent pain behavior in rats: Opposite contribution of frontal cortex and amygdala implied.Psych Journal,2(2),133-145.
MLA	Qi, Wei-Jing,et al."Depressive-like history alters persistent pain behavior in rats: Opposite contribution of frontal cortex and amygdala implied".Psych Journal 2.2(2013):133-145.