Evaluation of the Association Between Common Genetic Variants Near the ABCA1 Gene and Primary Angle Closure Glaucoma in a Han Chinese Population

	Evaluation of the Association Between Common Genetic Variants Near the ABCA1 Gene and Primary Angle Closure Glaucoma in a Han Chinese Population
	Luo, Huaichao; Chen, Yuhong; Ye, Zimeng; Sun, Xinghuai; Shi, Yi; Luo, Qian; Gong, Bo; Shuai, Ping; Yang, Jiyun; Zhou, Yu
刊名	INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
	2015
卷号	56 期号:11 页码:6248-6254
关键词	SINGLE NUCLEOTIDE POLYMORPHISMS SUSCEPTIBILITY RISK LOCI PACG MFRP
通讯作者	Yang, ZL (reprint author), Sichuan Prov Peoples Hosp, Sichuan Prov Key Lab Human Dis Gene Study, Inst Lab Med, 32 First Ring Rd West, Chengdu 610072, Sichuan, Peoples R China.
产权排序	2
合作状况	国内
英文摘要	PURPOSE. Recently, three large genome-wide association studies have identified multiple variants associated with primary open angle glaucoma (POAG) near the ABCA1 gene. Considering that POAG and primary angle closure glaucoma (PACG) share many similar clinical manifestations, the present study was conducted to investigate whether these genetic variants were also associated with PACG in a Han Chinese population. METHODS. A case-control association study of 1122 cases (PACG/PAC) and 1311 normal, matched controls was undertaken. Seven single-nucleotide polymorphisms (SNPs) near the ABCA1 gene, including rs2422493, rs2487042, rs2472496, rs2472493, rs2487032, rs2472459, and rs2472519, were genotyped. Genotype and allele frequencies were assessed using chi(2) tests. Linkage disequilibrium (LD) structure was analyzed by computer software. RESULTS. Among the SNPs genotyped, no association was observed between these SNPs and PACG. However, we discovered that two haplotypes, CATTTAC (corrected P = 0.048) and CGCCCGC (corrected P = 0.048), remained significantly associated with PACG/PAC after Bonferroni correction. Subjects with the CATTTAC haplotype have a 1.71-fold increased possibility of having PACG/PAC, whereas subjects with the CGCCCGC haplotype have 0.47-fold decreased possibility of developing PACG. CONCLUSIONS. Our findings suggest that the genetic backgrounds of PACG and POAG might be different. However, whether or not ABCA1 plays a role in the development of PACG is still not made certain by this study. Thus, further research is needed to find the role of ABCA1 in the progress of PACG.
学科主题	Ophthalmology
类目[WOS]	Ophthalmology
语种	英语
内容类型	期刊论文
源URL	[http://210.75.237.14/handle/351003/27566]
专题	成都生物研究所_天然产物研究
推荐引用方式 GB/T 7714	Luo, Huaichao,Chen, Yuhong,Ye, Zimeng,et al. Evaluation of the Association Between Common Genetic Variants Near the ABCA1 Gene and Primary Angle Closure Glaucoma in a Han Chinese Population[J]. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE,2015,56(11):6248-6254.
APA	Luo, Huaichao.,Chen, Yuhong.,Ye, Zimeng.,Sun, Xinghuai.,Shi, Yi.,...&Yang, Zhenglin.(2015).Evaluation of the Association Between Common Genetic Variants Near the ABCA1 Gene and Primary Angle Closure Glaucoma in a Han Chinese Population.INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE,56(11),6248-6254.
MLA	Luo, Huaichao,et al."Evaluation of the Association Between Common Genetic Variants Near the ABCA1 Gene and Primary Angle Closure Glaucoma in a Han Chinese Population".INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 56.11(2015):6248-6254.