Synthesis of water soluble chitosan derivatives with halogeno-1,2,3-triazole and their antifungal activity | |
Li, Q; Tan, WQ; Zhang, CL; Gu, GD; Guo, ZY | |
刊名 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES |
2016-10-01 | |
卷号 | 91页码:623-629 |
关键词 | Chitosan derivatives 1,2,3-Triazole Antifungal activity Halogens Electron-withdrawing capacity |
ISSN号 | 0141-8130 |
通讯作者 | Guo, ZY (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Shangdong, Peoples R China. Email:zhanyongguo@hotmail.com |
产权排序 | [Li, Qing; Tan, Wenqiang; Guo, Zhanyong] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Shangdong, Peoples R China; [Tan, Wenqiang] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China; [Zhang, Caili] Yantai Univ, Sch Chem & Chem Engn, Yantai 264005, Peoples R China; [Gu, Guodong] Alliance Pharma Inc, 17 Lee Blvd, Malvern, PA 19355 USA |
英文摘要 | Chitosan is an abundant and renewable polysaccharide, which exhibits attractive bioactivities and natural properties. Improvement such as chemical modification of chitosan is often performed prior to further utilization. Three novel water soluble chitosan derivatives containing 1,2,3- triazole with or without halogen was designed and synthesized. Their antifungal activity against three kinds of phytopathogens was estimated by hyphal measurement in vitro. The inhibitory property and water solubility of the synthesized chitosan derivatives exhibited a remarkable improvement over chitosan. It is hypothesized that thiazolyl groups enable the synthesized chitosan to possess obviously better antifungal activity. Moreover, CTCTS and BTCTS, which have halogens at the periphery of polymers, inhibited the growth of tested phytopathogens more effectively with inhibitory indices of 81-93% at 1.0 mg/mL. The halogens could have a synergistic effect with triazole as they exhibited antifungal activity and electron-withdrawing capacity, which improve the antifungal activity of chitosan derivatives. (C) 2016 Elsevier B.V. All rights reserved. |
研究领域[WOS] | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
关键词[WOS] | CLICK CHEMISTRY ; ANTIBACTERIAL ACTIVITY ; ANTITUMOR-ACTIVITY ; MAILLARD REACTION ; MOLECULAR-WEIGHT ; 1,2,4-TRIAZOLES ; INHIBITORS ; 1,2,3-TRIAZOLES ; ANTIOXIDANT ; CELLULASE |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000382339200072 |
内容类型 | 期刊论文 |
源URL | [http://ir.yic.ac.cn/handle/133337/17195] |
专题 | 烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室 海岸带生物资源高效利用研究与发展中心 |
推荐引用方式 GB/T 7714 | Li, Q,Tan, WQ,Zhang, CL,et al. Synthesis of water soluble chitosan derivatives with halogeno-1,2,3-triazole and their antifungal activity[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2016,91:623-629. |
APA | Li, Q,Tan, WQ,Zhang, CL,Gu, GD,&Guo, ZY.(2016).Synthesis of water soluble chitosan derivatives with halogeno-1,2,3-triazole and their antifungal activity.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,91,623-629. |
MLA | Li, Q,et al."Synthesis of water soluble chitosan derivatives with halogeno-1,2,3-triazole and their antifungal activity".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 91(2016):623-629. |
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