A New Diketopiperazine from the Marine Sponge Callyspongia Species

CORC > 南海海洋研究所 > 中国科学院南海海洋研究所 > 中科院海洋生物资源可持续利用重点实验室

	A New Diketopiperazine from the Marine Sponge Callyspongia Species
	Yang, Bin; Huang, Jingxia; Lin, Xiuping; Zhang, Yanying; Tao, Huaming; Liu, Yonghong
刊名	RECORDS OF NATURAL PRODUCTS
	2016
卷号	10 期号:1 页码:117-121
关键词	Callyspongia sp. Diketopiperazine Chemical constituents Antifouling activity
通讯作者	Liu, YH (reprint author), Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med,Res Ctr Marine M, Guangzhou 510301, Guangdong, Peoples R China.
中文摘要	Chemical investigation of the sponge Callyspongia sp. from the South China Sea afforded one new diketopiperazine, cyclo-(R-Pro-6-hydroxyl-S-Ile) (1), along with six known diketopiperazines: staphyloamide A (2), cyclo-(S-Pro-S-Phe) (3), cyclo-(R-Pro-R-Phe) (4), cyclo-(S-Pro-R-Leu) (5), cyclo-(S-Pro-R-Ala) (6), cyclo( R-Tyr-R-Phe) (7), and three known tryptophan-derived alkaloids: C-2-alpha-D-mannosylpyranosyl-tryptophan (8), (1R, 3S)-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid (9), and (1R, 3R)-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b] indole-3-carboxylic acid (10). The structures were determined on the basis of NMR and MS analysis, and the absolute configuration was determined by comparison of the optical rotation with the known compounds. This is the first report of compounds 1, 2, 8-10 from the sponge Callyspongia. Cyclo-(S-Pro-R-Leu) (5), and cyclo-(S-Pro-R-Ala) (6) exhibited antifouling activity against cyprid larvae of the barnacle with the LC50 values of 3.5 mu g/cm(2) and 6.0 mu g/cm(2), respectively.
学科主题	Plant Sciences; Chemistry; Pharmacology & Pharmacy
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/15528]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
推荐引用方式 GB/T 7714	Yang, Bin,Huang, Jingxia,Lin, Xiuping,et al. A New Diketopiperazine from the Marine Sponge Callyspongia Species[J]. RECORDS OF NATURAL PRODUCTS,2016,10(1):117-121.
APA	Yang, Bin,Huang, Jingxia,Lin, Xiuping,Zhang, Yanying,Tao, Huaming,&Liu, Yonghong.(2016).A New Diketopiperazine from the Marine Sponge Callyspongia Species.RECORDS OF NATURAL PRODUCTS,10(1),117-121.
MLA	Yang, Bin,et al."A New Diketopiperazine from the Marine Sponge Callyspongia Species".RECORDS OF NATURAL PRODUCTS 10.1(2016):117-121.