Two new anthraquinones with antiviral activities from the barks of Morinda citrifolia (Noni)

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	Two new anthraquinones with antiviral activities from the barks of Morinda citrifolia (Noni)
	Wang, Junfeng; Qin, Xiaochu; Chen, Zhiyun; Ju, Zhiran; He, Weijun; Tan, Yehui; Zhou, Xiaojiang; Tu, Zhengchao; Lu, Fangguo; Liu, Yonghong
刊名	PHYTOCHEMISTRY LETTERS
	2016
卷号	15 页码:13-15
关键词	Morinda citrifolia Anthraquinone Antiviral activity Antimicrobial activity
通讯作者	Liu, YH (reprint author), Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, South China Sea Inst Oceanol,RNAM Ctr Marine Micr, Guangzhou 510301, Guangdong, Peoples R China. ; Lu, FG (reprint author), Hunan Univ Chinese Med, Sch Med, Changsha 410208, Hunan, Peoples R China.
中文摘要	Two new anthraquinones, 1,3-dihydroxy-5-methoxy-6-methoxymethyl-2-methyl-9,10-anthraquinone (1) and 1,3-dihydroxy-5-methoxy-2,6-bismethoxymethyl-9,10-anthraquinone (2), together with ten known anthraquinone derivatives (3-12), three coumarin derivatives (13-15), and 6-gingerol (16) were isolated from the barks of Morinda citrifolia (Noni) collected in the Yongxing island of Xisha. The structures of compounds (1-16) were determined on the basis of extensive spectroscopic analyses, as well as by comparison with literature reports. The new compounds 1 and 2 were tested for their antiviral, cytotoxic, and antibacterial activities. In the primary bioassays, compounds 1 and 2 displayed weak antiH1N1 activity with IC50 values of 66.1 and 10.5 mu M, respectively. In addition, compound 2 showed weak anti-H3N2 activity with IC50 value of 11.5 mu M, and had weak antimicrobial activity against Staphylococcus aureus with MIC value of 24.5 mu M. (C) 2015 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
学科主题	Biochemistry & Molecular Biology; Plant Sciences
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/15489]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
推荐引用方式 GB/T 7714	Wang, Junfeng,Qin, Xiaochu,Chen, Zhiyun,et al. Two new anthraquinones with antiviral activities from the barks of Morinda citrifolia (Noni)[J]. PHYTOCHEMISTRY LETTERS,2016,15:13-15.
APA	Wang, Junfeng.,Qin, Xiaochu.,Chen, Zhiyun.,Ju, Zhiran.,He, Weijun.,...&Liu, Yonghong.(2016).Two new anthraquinones with antiviral activities from the barks of Morinda citrifolia (Noni).PHYTOCHEMISTRY LETTERS,15,13-15.
MLA	Wang, Junfeng,et al."Two new anthraquinones with antiviral activities from the barks of Morinda citrifolia (Noni)".PHYTOCHEMISTRY LETTERS 15(2016):13-15.