Elucidating the Cyclization Cascades in Xiamycin Biosynthesis by Substrate Synthesis and Enzyme Characterizations

CORC > 南海海洋研究所 > 中国科学院南海海洋研究所 > 中科院海洋生物资源可持续利用重点实验室

	Elucidating the Cyclization Cascades in Xiamycin Biosynthesis by Substrate Synthesis and Enzyme Characterizations
	Li, Huixian 1; Sun, Yu 1; Zhang, Qingbo 1; Zhu, Yiguang 1; Li, Shu-Ming 1; Li, Ang 1; Zhang, Changsheng 1
刊名	ORGANIC LETTERS
	2015
卷号	17 期号:2 页码:306-309
通讯作者	czhang2006@gmail.com
英文摘要	Indolosesquiterpene xiamycin A features a pentacyclic core structure. The chemical synthesis of two key precursors, 3-farnesylindole and 3-(epoxyfarnesyl)-indole, allowed elucidation of the enzymatic cascades forming the pentacyclic ring system of xiamycin A by XiaO-catalyzed epoxidation and the membrane protein XiaH-catalyzed terpene cyclization. The substrate flexibility of XiaI, an indole oxygenase for assembly of the central ring, was also demonstrated.
学科主题	Chemistry
原文出处	1523-7060
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/14882]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
作者单位	1.[Li, Huixian 2.Zhang, Qingbo 3.Zhu, Yiguang 4.Zhang, Changsheng] Chinese Acad Sci, Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510301, Guangdong, Peoples R China 5.[Sun, Yu 6.Li, Ang] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, Shanghai 200032, Peoples R China 7.[Li, Shu-Ming] Univ Marburg, Inst Pharmazeut Biol & Biotechnol, D-35037 Marburg, Germany
推荐引用方式 GB/T 7714	Li, Huixian,Sun, Yu,Zhang, Qingbo,et al. Elucidating the Cyclization Cascades in Xiamycin Biosynthesis by Substrate Synthesis and Enzyme Characterizations[J]. ORGANIC LETTERS,2015,17(2):306-309.
APA	Li, Huixian.,Sun, Yu.,Zhang, Qingbo.,Zhu, Yiguang.,Li, Shu-Ming.,...&Zhang, Changsheng.(2015).Elucidating the Cyclization Cascades in Xiamycin Biosynthesis by Substrate Synthesis and Enzyme Characterizations.ORGANIC LETTERS,17(2),306-309.
MLA	Li, Huixian,et al."Elucidating the Cyclization Cascades in Xiamycin Biosynthesis by Substrate Synthesis and Enzyme Characterizations".ORGANIC LETTERS 17.2(2015):306-309.