Five new phorbol esters with cytotoxic and selective anti-inflammatory activites from Croton tiglium

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	Five new phorbol esters with cytotoxic and selective anti-inflammatory activites from Croton tiglium
	Wang, Jun-Feng 1; Yang, Sheng-Hui 1; Liu, Yan-Qun 1; Li, Din-Xiang 1; He, Wei-Jun 1; Zhang, Xiao-Xiao 1; Liu, Yong-Hong 1; Zhou, Xiao-Jiang 1
刊名	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
	2015
卷号	25 期号:9 页码:1986-1989
关键词	Croton tiglium Phorbol esters Cytotoxicity Anti-inflammatory activity
通讯作者	yonghongliu@scsio.ac.cn ; gale9888@163.com
英文摘要	Five new phorbol esters, (four phorbol diesters, 1-4, and one 4-deoxy-4 alpha-phorbol diester, 5), as well as four known phorbol esters analogues (6-9) were isolated and identified from the branches and leaves of Croton tiglium. Their structures were elucidated mainly by extensive NMR spectroscopic, and mass spectrometric analysis. Among them, compound (1) was the first example of a naturally occurring phorbol ester with the 20-aldehyde group. Compounds 2-5, and 7-9 showed potent cytotoxicity against the K562, A549, DU145, H1975, MCF-7, U937, SGC-7901, HL60, Hela, and MOLT-4 cell lines, with IC50 values ranging from 1.0 to 43 mu M, while none of the compounds exhibited cytotoxic effects on normal human cell lines 293T and LX-2, respectively. In addition, compound 3 exhibited moderate COX-1 and COX-2 inhibition, with IC50 values of 0.14 and 8.5 mu M, respectively. (C) 2015 Elsevier Ltd. All rights reserved.
学科主题	Pharmacology & Pharmacy; Chemistry
原文出处	0960-894X
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/14837]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
作者单位	1.[Wang, Jun-Feng 2.Yang, Sheng-Hui 3.Liu, Yan-Qun 4.He, Wei-Jun 5.Zhang, Xiao-Xiao 6.Zhou, Xiao-Jiang] Hunan Univ Chinese Med, Coll Pharm, Changsha 410208, Hunan, Peoples R China 7.[Wang, Jun-Feng 8.Liu, Yong-Hong] Chinese Acad Sci, South China Sea Inst Oceanol, RNAM Ctr Marine Microbiol,Guangdong Key Lab Marin, CAS Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Guangdong, Peoples R China 9.[Li, Din-Xiang] Hunan Univ Chinese Med, Key Lab Hunan Prov Integrated Tradit Chinese & We, Changsha 410208, Hunan, Peoples R China
推荐引用方式 GB/T 7714	Wang, Jun-Feng,Yang, Sheng-Hui,Liu, Yan-Qun,et al. Five new phorbol esters with cytotoxic and selective anti-inflammatory activites from Croton tiglium[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2015,25(9):1986-1989.
APA	Wang, Jun-Feng.,Yang, Sheng-Hui.,Liu, Yan-Qun.,Li, Din-Xiang.,He, Wei-Jun.,...&Zhou, Xiao-Jiang.(2015).Five new phorbol esters with cytotoxic and selective anti-inflammatory activites from Croton tiglium.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,25(9),1986-1989.
MLA	Wang, Jun-Feng,et al."Five new phorbol esters with cytotoxic and selective anti-inflammatory activites from Croton tiglium".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 25.9(2015):1986-1989.