Dicarabrol, a new dimeric sesquiterpene from Carpesium abrotanoides L.

CORC > 南海海洋研究所 > 中国科学院南海海洋研究所 > 中科院海洋生物资源可持续利用重点实验室

	Dicarabrol, a new dimeric sesquiterpene from Carpesium abrotanoides L.
	Wang, Jun-Feng 1; He, Wei-Jun 1; Zhang, Xiao-Xiao 1; Zhao, Bi-Qing 1; Liu, Yong-Hong 1; Zhou, Xiao-Jiang 1
刊名	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
	2015
卷号	25 期号:19 页码:4082-4084
关键词	Dimeric sesquiterpene Carpesium abrotanoides L. Cytotoxic activity Antiviral activity Antimycobacterial activity
通讯作者	gale9888@163.com
英文摘要	A new dimeric sesquiterpene, dicarabrol (1), together with three known sesquiterpenes, carabrol (2), 11 (13)-dehydroivaxillin (3), and 2-desoxy-4-epi-pulchellin (4), were isolated from the whole plant of Carpesium abrotanoides L. Their structures were elucidated on the basis of spectroscopic analysis, and single crystal X-ray diffraction analysis. Compound 1 possessed a dimeric sesquiterpene core featured with a cyclopentane ring connecting two sesquiterpene lactone units rarely discovered in nature. Dicarabrol (1), as well as three known sesquiterpenes (2-4), had potent in vitro cytotoxicities against the K562, MCF-7, Hela, DU145, U937, H1975, SGC-7901, A549, MOLT-4, and HL60 cell lines with IC50 values ranging from 0.10 to 46.7 mu M, while they showed significant antiviral (H1N1 and H3N2) activities. Furthermore, compounds 1, 3 and 4 displayed significant antimycobacterial activity (IC50 3.7, 6.0, and 7.6 mu M, respectively). (C) 2015 Elsevier Ltd. All rights reserved.
学科主题	Pharmacology & Pharmacy; Chemistry
原文出处	0960-894X
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/14766]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
作者单位	1.[Wang, Jun-Feng 2.He, Wei-Jun 3.Zhang, Xiao-Xiao 4.Zhao, Bi-Qing 5.Zhou, Xiao-Jiang] Hunan Univ Chinese Med, Coll Pharm, Changsha 410208, Hunan, Peoples R China 6.[Wang, Jun-Feng 7.Liu, Yong-Hong] Chinese Acad Sci, South China Sea Inst Oceanol, RNAM Ctr Marine Microbiol, Guangdong Key Lab Marine Mat Med,CAS Key Lab Trop, Guangzhou 510301, Guangdong, Peoples R China
推荐引用方式 GB/T 7714	Wang, Jun-Feng,He, Wei-Jun,Zhang, Xiao-Xiao,et al. Dicarabrol, a new dimeric sesquiterpene from Carpesium abrotanoides L.[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2015,25(19):4082-4084.
APA	Wang, Jun-Feng,He, Wei-Jun,Zhang, Xiao-Xiao,Zhao, Bi-Qing,Liu, Yong-Hong,&Zhou, Xiao-Jiang.(2015).Dicarabrol, a new dimeric sesquiterpene from Carpesium abrotanoides L..BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,25(19),4082-4084.
MLA	Wang, Jun-Feng,et al."Dicarabrol, a new dimeric sesquiterpene from Carpesium abrotanoides L.".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 25.19(2015):4082-4084.