Cationic Poly(p-phenylene vinylene) Materials as a Multifunctional Platform for Light-Enhanced siRNA Delivery

	Cationic Poly(p-phenylene vinylene) Materials as a Multifunctional Platform for Light-Enhanced siRNA Delivery
	Li, Shengliang; Yuan, Huanxiang; Chen, Hui; Wang, Xiaoyu; Zhang, Pengbo; Lv, Fengting; Liu, Libing; Wang, Shu
刊名	CHEMISTRY-AN ASIAN JOURNAL
	2016-10-01
卷号	11 期号:19 页码:2686-2689
关键词	conjugated polyelectrolytes endosomal escape multifunction photochemistry siRNA delivery
英文摘要	In this work, a multifunctional platform based on the versatile function of cationic poly(p-phenylene vinylene) (PPV) derivative has been developed for white light-enhanced siRNA delivery in a remote control manner. Conjugated polyelectrolyte PPV, which possesses cationic and amphipathic features, can effectively self-assemble with siRNA and deliver siRNA into living cells. More importantly, PPV can sensitize surrounding oxygen into reactive oxygen species (ROS) upon exposure to white light and disrupt the endosomal membrane, and the resulting enhanced endosomal escape increases the gene silencing ability of siRNA. Besides, due to high fluorescent emission, PPV can also be used to image the siRNA delivery and intracelluar location. Therefore, by taking full advantage of PPV, this strategy provides a new enhanced siRNA delivery in a non-invasive and spatiotemporal photochemical manner.
收录类别	SCI
语种	英语
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/35093]
专题	化学研究所_有机固体实验室
作者单位	Chinese Acad Sci, Inst Chem, Key Lab Organ Solids, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Li, Shengliang,Yuan, Huanxiang,Chen, Hui,et al. Cationic Poly(p-phenylene vinylene) Materials as a Multifunctional Platform for Light-Enhanced siRNA Delivery[J]. CHEMISTRY-AN ASIAN JOURNAL,2016,11(19):2686-2689.
APA	Li, Shengliang.,Yuan, Huanxiang.,Chen, Hui.,Wang, Xiaoyu.,Zhang, Pengbo.,...&Wang, Shu.(2016).Cationic Poly(p-phenylene vinylene) Materials as a Multifunctional Platform for Light-Enhanced siRNA Delivery.CHEMISTRY-AN ASIAN JOURNAL,11(19),2686-2689.
MLA	Li, Shengliang,et al."Cationic Poly(p-phenylene vinylene) Materials as a Multifunctional Platform for Light-Enhanced siRNA Delivery".CHEMISTRY-AN ASIAN JOURNAL 11.19(2016):2686-2689.