Preparation of multicompartment silica-gelatin nanoparticles with self-decomposability as drug containers for cancer therapy in vitro

CORC > 化学研究所 > 中国科学院化学研究所 > 胶体、界面与化学热力学实验室

	Preparation of multicompartment silica-gelatin nanoparticles with self-decomposability as drug containers for cancer therapy in vitro
	Wang, Anhe 1; Yang, Yang 2; Yan, Xuehai 1; Ma, Guanghui 1; Bai, Shuo 1; Li, Junbai 2,3
刊名	RSC ADVANCES
	2016
卷号	6 期号:74 页码:70064-70071
英文摘要	We demonstrate multicompartment silica-gelatin nanoparticles (MSGNs), using gelatin doped CaCO3 particles as templates, with self-decomposability in response to body temperature as drug carriers for cancer therapy in vitro. The use of CaCO3 particles provides facile size control of MSGNs in nanoscale without using surfactants. Gelatin involved in the hybrid particles will cover the surface of particles, reducing the toxicity of silica materials caused by Si-OH groups, and moreover plays the role of the cement in the construction to hold the multicompartment structure. Above the gelation temperature, gelatin molecules can escape from particles resulting in the self-decomposition of MSGNs under body conditions. The obtained MSGNs have the potential to be used as an efficient carrier in cancer therapy.
收录类别	SCI
语种	英语
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/35391]
专题	化学研究所_胶体、界面与化学热力学实验室
作者单位	1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Inst Chem, Key Lab Colloid Interface & Chem Thermodynam, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Wang, Anhe,Yang, Yang,Yan, Xuehai,et al. Preparation of multicompartment silica-gelatin nanoparticles with self-decomposability as drug containers for cancer therapy in vitro[J]. RSC ADVANCES,2016,6(74):70064-70071.
APA	Wang, Anhe,Yang, Yang,Yan, Xuehai,Ma, Guanghui,Bai, Shuo,&Li, Junbai.(2016).Preparation of multicompartment silica-gelatin nanoparticles with self-decomposability as drug containers for cancer therapy in vitro.RSC ADVANCES,6(74),70064-70071.
MLA	Wang, Anhe,et al."Preparation of multicompartment silica-gelatin nanoparticles with self-decomposability as drug containers for cancer therapy in vitro".RSC ADVANCES 6.74(2016):70064-70071.