Extremely Stable Supramolecular Hydrogels Assembled from Nonionic Peptide Amphiphiles

	Extremely Stable Supramolecular Hydrogels Assembled from Nonionic Peptide Amphiphiles
	Wan, Yaoming 1; Wang, Zuoning 1; Sun, Jing 2; Li, Zhibo 1,2
刊名	LANGMUIR
	2016-08-02
卷号	32 期号:30 页码:7512-7518
英文摘要	Peptide hydrogels with high stability in different media are of great interest in biomedical applications. In this paper, we report an easy, fast, and scalable method for preparing a family of nonionic peptide amphiphiles (PAs) obtained by direct aminolysis of alkyl-oilgo(gamma-benzyl-L-glutamate) samples, which were synthesized via the alkyl amine-initiated sequence ring-opening reaction of alpha-amino acid N-carboxyanhydrides. One great advantage of this method is that vast chemical diversity and large-scale yields can be achieved easily using commercially available hydramines. These PA samples can readily form a clear hydrogel without any external aid and show exceptionally enhanced gelation properties with a critical gelation concentration as low as 0.05 wt %. The hydrogels are highly stable against extreme pH values of 1 and 14 and a high salt concentration of 200 mM NaCl. These properties combined with the shear-thinning properties make these PA hydrogels ideal candidates for the new generation of injectable scaffolds.
收录类别	SCI
语种	英语
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/35264]
专题	化学研究所_高分子物理与化学实验室
作者单位	1.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci BNLMS, Beijing 100190, Peoples R China 2.Qingdao Univ Sci & Technol, Sch Polymer Sci & Engn, Qingdao 266042, Peoples R China
推荐引用方式 GB/T 7714	Wan, Yaoming,Wang, Zuoning,Sun, Jing,et al. Extremely Stable Supramolecular Hydrogels Assembled from Nonionic Peptide Amphiphiles[J]. LANGMUIR,2016,32(30):7512-7518.
APA	Wan, Yaoming,Wang, Zuoning,Sun, Jing,&Li, Zhibo.(2016).Extremely Stable Supramolecular Hydrogels Assembled from Nonionic Peptide Amphiphiles.LANGMUIR,32(30),7512-7518.
MLA	Wan, Yaoming,et al."Extremely Stable Supramolecular Hydrogels Assembled from Nonionic Peptide Amphiphiles".LANGMUIR 32.30(2016):7512-7518.