Synthesis and multimodal responsiveness of poly(alpha-amino acid)s bearing OEGylated azobenzene side-chains

	Synthesis and multimodal responsiveness of poly(alpha-amino acid)s bearing OEGylated azobenzene side-chains
	Xiong, Wei 1; Fu, Xiaohui 2; Wan, Yaoming 3; Sun, Yunlong 1; Li, Zhibo 2; Lu, Hua 1
刊名	POLYMER CHEMISTRY
	2016
卷号	7 期号:41 页码:6375-6382
英文摘要	Stimuli-responsive poly(alpha-amino acids) (P alpha AAs) are protein mimics that can alter their conformational or other physicochemical properties in response to external triggers. We report here the synthesis and characterization of novel photo and thermal responsive P alpha AAs by the ring-opening polymerization of alpha-amino acid N-carboxyanhydrides (NCAs). Specifically, a series of NCA monomers bearing azobenzene (Azo) and oligoethylene glycol (OEG) of different lengths (OEG(m)-AzoNCA, m = 2, 4, 6) are synthesized in a modular route and polymerized in a controlled manner using hexamethyldisilazane (HMDS) as the initiator. The afforded P(OEG(m)-Azo)(n)s show interesting aggregation behaviors in both organic and aqueous solutions. Moreover, P(OEG(m)-Azo)(n)s exhibit a reversible photo-responsiveness accompanied by the conformational switch of the peptidic backbone, and an irreversible thermal-responsiveness. This new biodegradable and stimuli-responsive system holds considerable promise for applications such as on-demand delivery, liquid crystalline, and hierarchical self-assembly.
收录类别	SCI
语种	英语
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/35152]
专题	化学研究所_高分子物理与化学实验室
作者单位	1.Peking Univ, Beijing Natl Lab Mol Sci, Ctr Soft Matter Sci & Engn, Lab Polymer Chem & Phys,Minist Educ,Coll Chem & M, Beijing 100871, Peoples R China 2.Qingdao Univ Sci & Technol, Sch Polymer Sci & Engn, Qingdao 266042, Peoples R China 3.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Lab Polymer Phys & Chem, Inst Chem, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Xiong, Wei,Fu, Xiaohui,Wan, Yaoming,et al. Synthesis and multimodal responsiveness of poly(alpha-amino acid)s bearing OEGylated azobenzene side-chains[J]. POLYMER CHEMISTRY,2016,7(41):6375-6382.
APA	Xiong, Wei,Fu, Xiaohui,Wan, Yaoming,Sun, Yunlong,Li, Zhibo,&Lu, Hua.(2016).Synthesis and multimodal responsiveness of poly(alpha-amino acid)s bearing OEGylated azobenzene side-chains.POLYMER CHEMISTRY,7(41),6375-6382.
MLA	Xiong, Wei,et al."Synthesis and multimodal responsiveness of poly(alpha-amino acid)s bearing OEGylated azobenzene side-chains".POLYMER CHEMISTRY 7.41(2016):6375-6382.