Gadolinium polytungstate nanoclusters: a new theranostic with ultrasmall size and versatile properties for dual-modal MR/CT imaging and photothermal therapy/radiotherapy of cancer

CORC > 过程工程研究所 > 中国科学院过程工程研究所 > 湿法冶金清洁生产技术国家工程实验室

	Gadolinium polytungstate nanoclusters: a new theranostic with ultrasmall size and versatile properties for dual-modal MR/CT imaging and photothermal therapy/radiotherapy of cancer
	Yong, Yuan 1,2; Zhou, Liangjun 1,2; Zhang, Shuangshuang 3; Yan, Liang 1,2; Gu, Zhanjun 1,2; Zhang, Guangjin 3; Zhao, Yuliang 1,2
刊名	NPG ASIA MATERIALS
	2016-05-01
卷号	8 期号:8 页码:e273
ISSN号	1884-4049
英文摘要	The development of a new generation of nanoscaled theranostics with simple compositions and versatile properties to realize enhanced diagnoses and treatment outcomes and to avoid side effects is highly desirable but remains a great challenge. Here we report a new ultrasmall theranostic based on bovine serum albumin-coated GdW10O36 nanoclusters (GdW10NCs) as multifunctional theranostics for multifunctional bio-imaging, highly effective in vitro photothermal ablation of cancer cells and in vivo radiotherapy of tumors. The as-synthesized GdW10 NCs afford significantly enhanced computed tomography/magnetic resonance imaging signals and remarkable photothermal therapy (PTT)/radiotherapy therapy (RT) therapeutic effects for tumor treatment. Moreover, toxicity studies confirmed their low toxicity and efficient renal clearance, suggesting their potential for practical applications. These results indicated that the as-prepared GdW10 nanoclusters are promising as multifunctional nanotheranostics for multimodal imaging-guided PTT/RT of tumors. These results also encourage the further exploration of other polyoxometalate-based multifunctional nanotheranostics for cancer diagnoses and therapy.
WOS标题词	Science & Technology ; Technology
类目[WOS]	Materials Science, Multidisciplinary
研究领域[WOS]	Materials Science
关键词[WOS]	MRI CONTRAST AGENTS ; APOPTOTIC CELL-DEATH ; BOVINE SERUM-ALBUMIN ; DRUG-DELIVERY ; IN-VITRO ; SYNERGISTIC THERAPY ; GRAPHENE ANALOGS ; POLYOXOMETALATE ; NANOPARTICLES ; COMPLEXES
收录类别	SCI
语种	英语
WOS记录号	WOS:000379759400006
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/21231]
专题	过程工程研究所_湿法冶金清洁生产技术国家工程实验室
作者单位	1.Chinese Acad Sci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Inst High Energy Phys, Yuquan Rd 19b Shijingshan Dist, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Natl Ctr Nanosci & Technol China, Yuquan Rd 19b Shijingshan Dist, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Inst Proc Engn, Key Lab Green Proc & Engn, Zhongguancun South Rd 12 Haidian Dist, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Yong, Yuan,Zhou, Liangjun,Zhang, Shuangshuang,et al. Gadolinium polytungstate nanoclusters: a new theranostic with ultrasmall size and versatile properties for dual-modal MR/CT imaging and photothermal therapy/radiotherapy of cancer[J]. NPG ASIA MATERIALS,2016,8(8):e273.
APA	Yong, Yuan.,Zhou, Liangjun.,Zhang, Shuangshuang.,Yan, Liang.,Gu, Zhanjun.,...&Zhao, Yuliang.(2016).Gadolinium polytungstate nanoclusters: a new theranostic with ultrasmall size and versatile properties for dual-modal MR/CT imaging and photothermal therapy/radiotherapy of cancer.NPG ASIA MATERIALS,8(8),e273.
MLA	Yong, Yuan,et al."Gadolinium polytungstate nanoclusters: a new theranostic with ultrasmall size and versatile properties for dual-modal MR/CT imaging and photothermal therapy/radiotherapy of cancer".NPG ASIA MATERIALS 8.8(2016):e273.