Co-Assembly of Graphene Oxide and Albumin/Photosensitizer Nanohybrids towards Enhanced Photodynamic Therapy

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	Co-Assembly of Graphene Oxide and Albumin/Photosensitizer Nanohybrids towards Enhanced Photodynamic Therapy
	Xing, Ruirui 1,2,3; Jiao, Tifeng 1,2; Liu, Yamei 1,2; Ma, Kai 1,2; Zou, Qianli 3,4; Ma, Guanghui 3; Yan, Xuehai 3,4
刊名	POLYMERS
	2016-05-01
卷号	8 期号:5 页码:181
关键词	protein graphene oxide singlet oxygen generation co-assembly photodynamic therapy
ISSN号	2073-4360
英文摘要	The inactivation of photosensitizers before they reach the targeted tissues can be an important factor, which limits the efficacy of photodynamic therapy (PDT). Here, we developed co-assembled nanohybrids of graphene oxide (GO) and albumin/photosensitizer that have a potential for protecting the photosensitizers from the environment and releasing them in targeted sites, allowing for an enhanced PDT. The nanohybrids were prepared by loading the pre-assembled nanoparticles of chlorin e6 (Ce6) and bovine serum albumin (BSA) on GO via non-covalent interactions. The protection to Ce6 is evident from the inhibited fluorescence and singlet oxygen generation activities of Ce6-BSA-GO nanohybrids. Importantly, compared to free Ce6 and Ce6 directly loaded by GO (Ce6-GO), Ce6-BSA-GO nanohybrids showed enhanced cellular uptake and in vitro release of Ce6, leading to an improved PDT efficiency. These results indicate that the smart photosensitizer delivery system constructed by co-assembly of GO and albumin is promising to improve the stability, biocompatibility, and efficiency of PDT.
WOS标题词	Science & Technology ; Physical Sciences
类目[WOS]	Polymer Science
研究领域[WOS]	Polymer Science
关键词[WOS]	BOVINE SERUM-ALBUMIN ; DRUG-DELIVERY ; NANOPARTICLES ; DESIGN ; NANOARCHITECTONICS ; PHOTOSENSITIZER ; DEGRADATION ; LIFETIME ; PROBE ; FILMS
收录类别	SCI
语种	英语
WOS记录号	WOS:000377795200021
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/21166]
专题	过程工程研究所_生化工程国家重点实验室
作者单位	1.Yanshan Univ, State Key Lab Metastable Mat Sci & Technol, Qinhuangdao 066004, Peoples R China 2.Yanshan Univ, Sch Environm & Chem Engn, Hebei Key Lab Appl Chem, Qinhuangdao 066004, Peoples R China 3.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China 4.Chinese Acad Sci, Inst Proc Engn, Ctr Mesosci, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Xing, Ruirui,Jiao, Tifeng,Liu, Yamei,et al. Co-Assembly of Graphene Oxide and Albumin/Photosensitizer Nanohybrids towards Enhanced Photodynamic Therapy[J]. POLYMERS,2016,8(5):181.
APA	Xing, Ruirui.,Jiao, Tifeng.,Liu, Yamei.,Ma, Kai.,Zou, Qianli.,...&Yan, Xuehai.(2016).Co-Assembly of Graphene Oxide and Albumin/Photosensitizer Nanohybrids towards Enhanced Photodynamic Therapy.POLYMERS,8(5),181.
MLA	Xing, Ruirui,et al."Co-Assembly of Graphene Oxide and Albumin/Photosensitizer Nanohybrids towards Enhanced Photodynamic Therapy".POLYMERS 8.5(2016):181.