Transmembrane channel-like (tmc) gene regulates Drosophila larval locomotion

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	Transmembrane channel-like (tmc) gene regulates Drosophila larval locomotion
	Guo, YM; Wang, YP; Zhang, W; Meltzer, S; Zanini, D; Yu, Y; Li, JF; Cheng, T; Guo, ZH; Wang, QX
刊名	PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
	2016
卷号	113 期号:26 页码:7243-7248
关键词	CELL MECHANOTRANSDUCER CHANNELS MULTIDENDRITIC SENSORY NEURONS COCHLEAR HAIR-CELLS C. ELEGANS MECHANICAL NOCICEPTION DEG/ENAC CHANNEL TRP CHANNELS HEARING-LOSS INNER-EAR NOMPC
通讯作者	Wang, ZR (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Ctr Excellence Brain Sci & Intelligence Technol, State Key Lab Neurosci,Inst Neurosci, Shanghai 200031, Peoples R China. ; Jan, YN (reprint author), Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94158 USA. ; Jan, YN (reprint author), Univ Calif San Francisco, Dept Biochem, San Francisco, CA 94158 USA. ; Jan, YN (reprint author), Univ Calif San Francisco, Dept Biophys, San Francisco, CA 94158 USA. ; Jan, YN (reprint author), Univ Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94158 USA.,yuhnung.jan@ucsf.edu ; zuorenwang@ion.ac.cn
英文摘要	Drosophila larval locomotion, which entails rhythmic body contractions, is controlled by sensory feedback from proprioceptors. The molecular mechanisms mediating this feedback are little understood. By using genetic knock-in and immunostaining, we found that the Drosophila melanogaster transmembrane channel-like (tmc) gene is expressed in the larval class I and class II dendritic arborization (da) neurons and bipolar dendrite (bd) neurons, both of which are known to provide sensory feedback for larval locomotion. Larvae with knockdown or loss of tmc function displayed reduced crawling speeds, increased head cast frequencies, and enhanced backward locomotion. Expressing Drosophila TMC or mammalian TMC1 and/or TMC2 in the tmc-positive neurons rescued these mutant phenotypes. Bending of the larval body activated the tmc-positive neurons, and in tmc mutants this bending response was impaired. This implicates TMC's roles in Drosophila proprioception and the sensory control of larval locomotion. It also provides evidence for a functional conservation between Drosophila and mammalian TMCs.
学科主题	Multidisciplinary Sciences
WOS标题词	Science & Technology - Other Topics
语种	英语
WOS记录号	WOS:000379033400072
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/4017]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Guo, YM,Wang, YP,Zhang, W,et al. Transmembrane channel-like (tmc) gene regulates Drosophila larval locomotion[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2016,113(26):7243-7248.
APA	Guo, YM.,Wang, YP.,Zhang, W.,Meltzer, S.,Zanini, D.,...&Wang, ZR.(2016).Transmembrane channel-like (tmc) gene regulates Drosophila larval locomotion.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,113(26),7243-7248.
MLA	Guo, YM,et al."Transmembrane channel-like (tmc) gene regulates Drosophila larval locomotion".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 113.26(2016):7243-7248.