Water as Co-Hydrogen Donor in Reductive Aminations | |
Ke ZG(柯振刚)1,2; Cui XJ(崔新江)1; Shi F(石峰)1 | |
刊名 | ACS Sustainable Chemistry and Engineering |
2016 | |
卷号 | 4期号:7页码:3921-3926 |
关键词 | Amine Formaldehyde N-Methylation Water reducing agent Nanogold |
ISSN号 | 2168-0485 |
通讯作者 | 石峰 |
英文摘要 | Reductive amination generates an important reaction in fine chemical synthesis. The employment of water as the hydrogen donor for reductive amination might solve the long-time hydrogen supply problem. Here, we present our new results on reductive N-methylation reactions of amine with paraformaldehyde with water as the co-hydrogen donor catalyzed by a simple supported nanogold catalyst, i.e., Au/Al2O3. N-Methyl amines or N,N-dimethyl amines can be selectively synthesized with excellent yields. Isotope tracing reactions confirmed the transformation of hydrogen from water in the final product. In addition, this method can be applied in the N-methylation reactions of bioactive molecules with excellent performance. This concept may supply a potential methodology for sustainable reductive amination. |
学科主题 | 物理化学与绿色催化 |
收录类别 | SCI |
资助信息 | the National Natural Science Foundation of China (21303228);Youth Innovation Promotion Association CAS |
语种 | 英语 |
WOS记录号 | WOS:000380291200041 |
内容类型 | 期刊论文 |
源URL | [http://210.77.64.217/handle/362003/20245] |
专题 | 兰州化学物理研究所_OSSO国家重点实验室 兰州化学物理研究所_绿色化学研究发展中心 |
作者单位 | 1.Chinese Acad Sci, Lanzhou Inst Chem Phys, Ctr Green Chem & Catalysis, State Key Lab Oxo Synth & Select Oxidat, 18 Tianshui Middle Rd, Lanzhou 730000, Peoples R China 2.Univ Chinese Acad Sci, 19A Yuquanlu, Beijing 100049, Peoples R China |
推荐引用方式 GB/T 7714 | Ke ZG,Cui XJ,Shi F. Water as Co-Hydrogen Donor in Reductive Aminations[J]. ACS Sustainable Chemistry and Engineering,2016,4(7):3921-3926. |
APA | Ke ZG,Cui XJ,&Shi F.(2016).Water as Co-Hydrogen Donor in Reductive Aminations.ACS Sustainable Chemistry and Engineering,4(7),3921-3926. |
MLA | Ke ZG,et al."Water as Co-Hydrogen Donor in Reductive Aminations".ACS Sustainable Chemistry and Engineering 4.7(2016):3921-3926. |
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