Evolution of Gene Regulation during Transcription and Translation

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	Evolution of Gene Regulation during Transcription and Translation
	Wang, Zhe 1; Sun, Xuepeng 1,2; Zhao, Yi 1,3; Guo, Xiaoxian 1; Jiang, Huifeng 1,4; Li, Hongye 2; Gu, Zhenglong 1
刊名	GENOME BIOLOGY AND EVOLUTION
	2015-04-01
卷号	7 期号:4 页码:1155-1167
关键词	evolution of gene regulation RNA-Seq ribosomal profiling
英文摘要	Understanding how gene regulation evolves is a key area in the current evolutionary field. Gene regulation occurs at various levels. Previous work on the evolution of gene regulation has largely focused on gene transcription. In this study, we used a recently developed ribosomal footprint profiling method to investigate how gene regulation evolves at both the transcription (mRNA abundance) and translation (ribosomal density) levels. By constructing a hybrid between Saccharomyces cerevisiae (Scer) and Saccharomyces bayanus (Sbay), which diverged similar to 20 Ma, and quantifying transcriptome and translatome in both parental strains and their hybrid, we showed that translation is much more conserved than transcription, mostly due to the buffering effect of translational regulation for the transcriptional divergence. More conservation in translation than transcription is also confirmed by the inheritance mode of transcription and translation between two species. Furthermore, cis and trans effects are widely involved in changes at both transcription and translation levels. Finally, our results showed that genes with certain functions and sequence features might employ specific modes for evolution at these two critical levels of gene regulation. Our results demonstrated that it is essential to investigate the evolution of gene regulation at various levels from different genetic backgrounds to obtain a complete picture of its evolutionary modes in nature.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Evolutionary Biology ; Genetics & Heredity
研究领域[WOS]	Evolutionary Biology ; Genetics & Heredity
关键词[WOS]	PROTEIN EXPRESSION ; YEAST HYBRID ; CIS ; DIVERGENCE ; GENOME ; TRANS ; MECHANISMS ; SACCHAROMYCES ; ELEMENTS ; REVEALS
收录类别	SCI
语种	英语
WOS记录号	WOS:000355148800019
内容类型	期刊论文
源URL	[http://124.16.173.210/handle/834782/1482]
专题	天津工业生物技术研究所_酵母基因组工程课题组江会锋_期刊论文
作者单位	1.Cornell Univ, Div Nutr Sci, Ithaca, NY 14853 USA 2.Zhejiang Univ, Coll Agr & Biotechnol, Hangzhou 310003, Zhejiang, Peoples R China 3.Dalian Med Univ, Affiliated Hosp 1, Dept Oncol, Dalian, Peoples R China 4.Chinese Acad Sci, Inst Tianjin Ind Biotechnol, Key Lab Syst Microbial Biotechnol, Tianjin, Peoples R China
推荐引用方式 GB/T 7714	Wang, Zhe,Sun, Xuepeng,Zhao, Yi,et al. Evolution of Gene Regulation during Transcription and Translation[J]. GENOME BIOLOGY AND EVOLUTION,2015,7(4):1155-1167.
APA	Wang, Zhe.,Sun, Xuepeng.,Zhao, Yi.,Guo, Xiaoxian.,Jiang, Huifeng.,...&Gu, Zhenglong.(2015).Evolution of Gene Regulation during Transcription and Translation.GENOME BIOLOGY AND EVOLUTION,7(4),1155-1167.
MLA	Wang, Zhe,et al."Evolution of Gene Regulation during Transcription and Translation".GENOME BIOLOGY AND EVOLUTION 7.4(2015):1155-1167.