Cell adhesion molecule pathway genes are regulated by cis-regulatory SNPs and show significantly altered expression in Alzheimer's disease brains

	Cell adhesion molecule pathway genes are regulated by cis-regulatory SNPs and show significantly altered expression in Alzheimer's disease brains
	Bao, Xinjie 1,2; Liu, Gengfeng 3; Jiang, Yongshuai 4; Jiang, Qinghua 5; Liao, Mingzhi 4; Feng, Rennan 6; Zhang, Liangcai 7; Ma, Guoda 8; Zhang, Shuyan 9; Chen, Zugen 10
刊名	NEUROBIOLOGY OF AGING
	2015-10-01
卷号	36 期号:10
关键词	Genome-wide association studies Alzheimer's disease Pathway analysis Cell adhesion molecules Brain expression
英文摘要	We previously identified the cell adhesion molecule (CAM) pathway as a consistent signal in 2 Alzheimer's disease (AD) genome-wide association studies (GWAS). However, the genetic mechanisms of the CAM pathway in AD are unclear. Here, we conducted pathway analysis using (1) Kyoto Encyclopedia of Genes and Genomes and Gene Ontology pathways; (2) 4 brain expression GWAS datasets; and (3) 2 whole-genome AD case-control expression datasets. Using the 4 brain expression GWAS datasets, we identified that genes regulated by cis-regulatory single-nucleotide polymorphisms (SNPs) were significantly enriched in the CAM pathway (p = 2.05E-06, p = 6.10E-07, p = 2.05E-06, and p = 1.47E-07 for each dataset). Interestingly, CAM is a significantly enriched pathway using down-regulated genes (raw p = 0.0235 and adjusted p = 0.0305) and all differentially expressed genes (raw p = 0.0105 and adjusted p = 0.0156) in dataset 5, and all differentially expressed genes (raw p = 0.0041 and adjusted p = 0.0062) in dataset 6. Collectively, our results show that CAM pathway genes are regulated by cis-regulatory SNPs and show significantly altered expression in AD. We believe that our results advance the understanding of AD mechanisms and will be useful for future genetic studies of AD. (C) 2015 Elsevier Inc. All rights reserved.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Geriatrics & Gerontology ; Neurosciences
研究领域[WOS]	Geriatrics & Gerontology ; Neurosciences & Neurology
关键词[WOS]	GENOME-WIDE ASSOCIATION ; DATA SETS ; SYSTEM ; IMPAIRMENT ; NETWORKS ; GENETICS ; FUTURE ; BACK
收录类别	SCI
语种	英语
WOS记录号	WOS:000360929100029
内容类型	期刊论文
源URL	[http://124.16.173.210/handle/834782/1569]
专题	天津工业生物技术研究所_基因组分析实验室陈祖耕_期刊论文
作者单位	1.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Neurosurg, Beijing 100730, Peoples R China 2.Peking Union Med Coll, Beijing 100730, Peoples R China 3.First Hosp Harbin, Cadre Ward, Harbin, Peoples R China 4.Harbin Med Univ, Coll Bioinformat Sci & Technol, Harbin, Peoples R China 5.Harbin Inst Technol, Sch Life Sci & Technol, Harbin 150006, Peoples R China 6.Harbin Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Harbin, Peoples R China 7.Rice Univ, Dept Stat, Houston, TX 77251 USA 8.Guangdong Med Coll, Inst Neurol, Zhanjiang 524001, Peoples R China 9.Harbin Med Univ, Affiliated Hosp 4, Dept Neurol, Harbin, Peoples R China 10.Univ Calif Los Angeles, Dept Human Genet, Los Angeles, CA USA
推荐引用方式 GB/T 7714	Bao, Xinjie,Liu, Gengfeng,Jiang, Yongshuai,et al. Cell adhesion molecule pathway genes are regulated by cis-regulatory SNPs and show significantly altered expression in Alzheimer's disease brains[J]. NEUROBIOLOGY OF AGING,2015,36(10).
APA	Bao, Xinjie.,Liu, Gengfeng.,Jiang, Yongshuai.,Jiang, Qinghua.,Liao, Mingzhi.,...&Liu, Guiyou.(2015).Cell adhesion molecule pathway genes are regulated by cis-regulatory SNPs and show significantly altered expression in Alzheimer's disease brains.NEUROBIOLOGY OF AGING,36(10).
MLA	Bao, Xinjie,et al."Cell adhesion molecule pathway genes are regulated by cis-regulatory SNPs and show significantly altered expression in Alzheimer's disease brains".NEUROBIOLOGY OF AGING 36.10(2015).