Structures and Receptor Binding of Hemagglutinins from Human-Infecting H7N9 Influenza Viruses

CORC > 天津工业生物技术研究所 > 蛋白质工程与疫苗实验室高福 > 期刊论文

	Structures and Receptor Binding of Hemagglutinins from Human-Infecting H7N9 Influenza Viruses
	Shi, Yi 1,2; Zhang, Wei 2,3; Wang, Fei 2,4; Qi, Jianxun 2; Wu, Ying 2; Song, Hao 2,3; Gao, Feng 5; Bi, Yuhai 2; Zhang, Yanfang 6; Fan, Zheng 7
刊名	SCIENCE
	2013-10-11
卷号	342 期号:6155 页码:243-247
英文摘要	An avian-origin human-infecting influenza (H7N9) virus was recently identified in China. We have evaluated the viral hemagglutinin (HA) receptor-binding properties of two human H7N9 isolates, A/Shanghai/1/2013 (SH-H7N9) (containing the avian-signature residue Gln(226)) and A/Anhui/1/2013 (AH-H7N9) (containing the mammalian-signature residue Leu(226)). We found that SH-H7N9 HA preferentially binds the avian receptor analog, whereas AH-H7N9 HA binds both avian and human receptor analogs. Furthermore, an AH-H7N9 mutant HA (Leu(226) -> Gln) was found to exhibit dual receptor-binding property, indicating that other amino acid substitutions contribute to the receptor-binding switch. The structures of SH-H7N9 HA, AH-H7N9 HA, and its mutant in complex with either avian or human receptor analogs show how AH-H7N9 can bind human receptors while still retaining the avian receptor-binding property.
WOS标题词	Science & Technology
类目[WOS]	Multidisciplinary Sciences
研究领域[WOS]	Science & Technology - Other Topics
关键词[WOS]	A VIRUS ; CONFORMATIONAL-ANALYSIS ; HUMAN CONJUNCTIVITIS ; TRANSMISSION ; SPECIFICITY ; ORIGIN ; SIALYLOLIGOSACCHARIDES ; COMPLEXES ; SELECTION ; OUTBREAK
收录类别	SCI
语种	英语
WOS记录号	WOS:000325475200044
内容类型	期刊论文
源URL	[http://124.16.173.210/handle/834782/1268]
专题	天津工业生物技术研究所_蛋白质工程与疫苗实验室高福_期刊论文
作者单位	1.Chinese Acad Sci, Beijing Inst Life Sci, Res Network Immun & Hlth, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.China Agr Univ, Coll Vet Med, Beijing 100193, Peoples R China 5.Chinese Acad Sci, Inst Biophys, Lab Noncoding RNA, Beijing 100101, Peoples R China 6.Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Lab Prot Engn & Vaccines, Tianjin 300308, Peoples R China 7.Chinese Acad Sci, Inst Microbiol, Core Facil, Beijing 100101, Peoples R China 8.Beijing Inst Microbiol & Epidemiol, Dept Virol, Beijing 100071, Peoples R China 9.Chinese Ctr Dis Control & Prevent China CDC, Natl Inst Viral Dis Control & Prevent, Beijing 102206, Peoples R China 10.China CDC, Off Director Gen, Beijing 102206, Peoples R China
推荐引用方式 GB/T 7714	Shi, Yi,Zhang, Wei,Wang, Fei,et al. Structures and Receptor Binding of Hemagglutinins from Human-Infecting H7N9 Influenza Viruses[J]. SCIENCE,2013,342(6155):243-247.
APA	Shi, Yi.,Zhang, Wei.,Wang, Fei.,Qi, Jianxun.,Wu, Ying.,...&Gao, George F..(2013).Structures and Receptor Binding of Hemagglutinins from Human-Infecting H7N9 Influenza Viruses.SCIENCE,342(6155),243-247.
MLA	Shi, Yi,et al."Structures and Receptor Binding of Hemagglutinins from Human-Infecting H7N9 Influenza Viruses".SCIENCE 342.6155(2013):243-247.