Bioactive sesquiterpenoids from the flowers of Inula japonica

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Bioactive sesquiterpenoids from the flowers of Inula japonica
	Wu, Xing-De; Ding, Lin-Fen; Tu, Wen-Chao; Yang, Hui; Su, Jia; Peng, Li-Yan; Li, Yan; Zhao, Qin-Shi
刊名	PHYTOCHEMISTRY
	2016-09-01
卷号	129 页码:68-76
关键词	Inula japonica Asteraceae Sesquiterpenoids Inujaponins A-I Cytotoxicity Nitric oxide (NO)
英文摘要	Phytochemical investigation of the flowers of Inula japonica led to isolation of nine sesquiterpenoids, inujaponins A-I, as well as eighteen known ones. These sesquiterpenoids belong to six skeletal-types, including eudesmane, 1,10-seco-eudesmane, germacrane, guaiane, 4,5-seco-guaiane, and pseudoguaiane sesquiterpenoids. Their structures were established by extensive spectroscopic analysis. The absolute configurations of inujaponin A, eupatolide, and deacetylovatifolin were determined by Cu-K alpha Xray crystallographic analysis. Most of the isolated compounds exhibited potent cytotoxicity against HL 60, SMMC-7721, A-549, MCF-7, and SW-480 cancer cell lines, with IC50 values ranging from 1.57 to 22.58 mu M. Some selected compounds also possessed significant inhibitory activity against LPS-induced NO production in RAW264.7 macrophages with IC50 values ranging from 1.42 to 8.99 mu M. (C) 2016 Elsevier Ltd. All rights reserved.
类目[WOS]	Biochemistry & Molecular Biology ; Plant Sciences
研究领域[WOS]	Biochemistry & Molecular Biology ; Plant Sciences
关键词[WOS]	NITRIC-OXIDE PRODUCTION ; LACTONES ; BRITANNICA ; CONSTITUENTS ; THUNB
收录类别	SCI
语种	英语
WOS记录号	WOS:000381832900007
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/28575]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
推荐引用方式 GB/T 7714	Wu, Xing-De,Ding, Lin-Fen,Tu, Wen-Chao,et al. Bioactive sesquiterpenoids from the flowers of Inula japonica[J]. PHYTOCHEMISTRY,2016,129:68-76.
APA	Wu, Xing-De.,Ding, Lin-Fen.,Tu, Wen-Chao.,Yang, Hui.,Su, Jia.,...&Zhao, Qin-Shi.(2016).Bioactive sesquiterpenoids from the flowers of Inula japonica.PHYTOCHEMISTRY,129,68-76.
MLA	Wu, Xing-De,et al."Bioactive sesquiterpenoids from the flowers of Inula japonica".PHYTOCHEMISTRY 129(2016):68-76.