Pepluane and Paraliane Diterpenoids from Euphorbia peplus with Potential Anti-inflammatory Activity

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Pepluane and Paraliane Diterpenoids from Euphorbia peplus with Potential Anti-inflammatory Activity
	Wan, Luo-Sheng 1; Chu, Rui 1,2; Peng, Xing-Rong 1; Zhu, Guo-Lei 1,2; Yu, Mu-Yuan1,2 ; Li, Lei 1,2; Zhou, Lin 1; Lu, Shuang-Yang 1,2; Dong, Jin-Run 1,2; Zhang, Zhi-Run 1
刊名	JOURNAL OF NATURAL PRODUCTS
	2016-06-01
卷号	79 期号:6 页码:1628-1634
英文摘要	Twelve new diterpenoids based on two rare skeletal types, namely, paralianones A-D (1-4) and pepluanols A-H (5-12), along with five known compounds, were isolated from an acetone extract of Euphorbia peplus. Their structures were proposed based on 1D and 2D NMR spectroscopic data analysis. These diterpenoids were evaluated for potential anti-inflammatory activity in a lipopolysaccharidestimulated mouse macrophage cellular model. Compounds 3, 4, 11, 13, and 16 displayed moderate inhibitory effects on NO inhibition, with IC50 values ranging from 29.9 to 38.3 mu M.
类目[WOS]	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]	Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]	INGENOL MEBUTATE ; DISCOVERY
收录类别	SCI
语种	英语
WOS记录号	WOS:000378758200018
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/26297]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Wan, Luo-Sheng,Chu, Rui,Peng, Xing-Rong,et al. Pepluane and Paraliane Diterpenoids from Euphorbia peplus with Potential Anti-inflammatory Activity[J]. JOURNAL OF NATURAL PRODUCTS,2016,79(6):1628-1634.
APA	Wan, Luo-Sheng.,Chu, Rui.,Peng, Xing-Rong.,Zhu, Guo-Lei.,Yu, Mu-Yuan.,...&Qiu, Ming-Hua.(2016).Pepluane and Paraliane Diterpenoids from Euphorbia peplus with Potential Anti-inflammatory Activity.JOURNAL OF NATURAL PRODUCTS,79(6),1628-1634.
MLA	Wan, Luo-Sheng,et al."Pepluane and Paraliane Diterpenoids from Euphorbia peplus with Potential Anti-inflammatory Activity".JOURNAL OF NATURAL PRODUCTS 79.6(2016):1628-1634.