LC-MS guided isolation of ent-kaurane diterpenoids from Nouelia insignis

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	LC-MS guided isolation of ent-kaurane diterpenoids from Nouelia insignis
	Sun, Chang-Li 1,2; Geng, Chang-An1 ; Chen, Xing-Long 1,2; Yang, Tong-Hua 1,2; Yin, Xiu-Juan 1,2; Huang, Xiao-Yan 1; Peng, Hua3 ; Chen, Ji-Jun1
刊名	FITOTERAPIA
	2016-06-01
卷号	111 页码:42-48
关键词	Nouelia insignis LC-MS Diterpenoids Nitric oxide production inhibitory activity
英文摘要	The preliminary LC-MS investigation on the stems of Nouelia insignis manifested the existence of diterpenoids. As a result, 15 ent-kaurane diterpenoids, including 7 new glycosides (nouelosides A-G, 1-7), were isolated under the direction of LC-MS analysis. The new compounds were determined by extensive spectroscopic analysis including HRESIMS, 1D and 2D NMR data and chemical methods. Compounds 6 and 15 with the exo-methylene cyclopentanone functional group exhibited obvious nitric oxide production inhibitory activity with IC50 values of 3.84 +/- 0.20 and 3.19 +/- 0.25 mu M. (C) 2016 Elsevier B.V. All rights reserved.
类目[WOS]	Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]	Pharmacology & Pharmacy
关键词[WOS]	LIQUID-CHROMATOGRAPHY ; CHEMICAL-CONSTITUENTS ; HEPATITIS
收录类别	SCI
语种	英语
WOS记录号	WOS:000377834300008
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/26279]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, Key Lab Biodivers & Biogeog, Kunming 650201, Peoples R China
推荐引用方式 GB/T 7714	Sun, Chang-Li,Geng, Chang-An,Chen, Xing-Long,et al. LC-MS guided isolation of ent-kaurane diterpenoids from Nouelia insignis[J]. FITOTERAPIA,2016,111:42-48.
APA	Sun, Chang-Li.,Geng, Chang-An.,Chen, Xing-Long.,Yang, Tong-Hua.,Yin, Xiu-Juan.,...&Chen, Ji-Jun.(2016).LC-MS guided isolation of ent-kaurane diterpenoids from Nouelia insignis.FITOTERAPIA,111,42-48.
MLA	Sun, Chang-Li,et al."LC-MS guided isolation of ent-kaurane diterpenoids from Nouelia insignis".FITOTERAPIA 111(2016):42-48.