EpicochalasinesA and B: Two Bioactive Merocytochalasans Bearing Caged Epicoccine Dimer Units from Aspergillus flavipes

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	EpicochalasinesA and B: Two Bioactive Merocytochalasans Bearing Caged Epicoccine Dimer Units from Aspergillus flavipes
	Zhu, Hucheng 1; Chen, Chunmei 1; Tong, Qingyi 1; Li, Xiao-Nian 2; Yang, Jing2 ; Xue, Yongbo 1; Luo, Zengwei 1; Wang, Jianping 1; Yao, Guangmin 1; Zhang, Yonghui 1
刊名	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
	2016-03-01
卷号	55 期号:10 页码:3486-3490
关键词	alkaloids biological activity fungal natural products polycycles structural elucidation
英文摘要	Two bioactive merocytochalasans, epicochalasinesA (1) and B (2), a new class of cytochalasans bearing unexpected scaffolds consisting of fused aspochalasin and epicoccine dimer moieties, were isolated from the liquid culture broth of Aspergillus flavipes. Both 1 and 2 possess a hendecacyclic 5/6/11/5/6/5/6/5/6/6/5 ring system containing an adamantyl cage and as many as 19 stereogenic centers; however, the fusion patterns of 1 and 2 differ greatly, thus resulting in different carbon skeletons. The absolute configurations of 1 and 2 were determined by X-ray diffraction and calculated ECD, respectively. The biogenetic pathways of 1 and 2 are proposed to involve Diels-Alder and nucleophilic addition reactions. Both 1 and 2 induced significant G2/M-phase cell-cycle arrest. Furthermore, we found that merocytochalasans induce apoptosis in leukemia cells through the activation of caspase-3 and the degradation of PARP.
类目[WOS]	Chemistry, Multidisciplinary
研究领域[WOS]	Chemistry
关键词[WOS]	CHAETOMIUM-GLOBOSUM TW1-1 ; RING-SYSTEM ; CHAETOGLOBOSIN ; CYTOCHALASANS ; BIOSYNTHESIS ; ALKALOIDS ; CELLS
收录类别	SCI
语种	英语
WOS记录号	WOS:000371418200050
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/26002]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
推荐引用方式 GB/T 7714	Zhu, Hucheng,Chen, Chunmei,Tong, Qingyi,et al. EpicochalasinesA and B: Two Bioactive Merocytochalasans Bearing Caged Epicoccine Dimer Units from Aspergillus flavipes[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2016,55(10):3486-3490.
APA	Zhu, Hucheng.,Chen, Chunmei.,Tong, Qingyi.,Li, Xiao-Nian.,Yang, Jing.,...&Zhang, Yonghui.(2016).EpicochalasinesA and B: Two Bioactive Merocytochalasans Bearing Caged Epicoccine Dimer Units from Aspergillus flavipes.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,55(10),3486-3490.
MLA	Zhu, Hucheng,et al."EpicochalasinesA and B: Two Bioactive Merocytochalasans Bearing Caged Epicoccine Dimer Units from Aspergillus flavipes".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 55.10(2016):3486-3490.